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Method for acquiring plasma specific protein for schizophrenia diagnosis and use thereof

An acquisition method, a specific technology, applied in the measurement of color/spectral properties, analysis by chemical reaction of materials, material analysis by observing the effect on chemical indicators, etc. There are few articles that can solve schizophrenia, etc. problems, to achieve the effect of convenient material collection and promotion of the process

Inactive Publication Date: 2007-02-14
SHANGHAI JIAO TONG UNIV
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  • Abstract
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Problems solved by technology

[0006] The study of schizophrenia at the level of plasma proteome provides new hope for the diagnosis and treatment of this disease, and the technological development of proteomics also provides favorable conditions for researchers. There are still very few articles on the disease

Method used

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  • Method for acquiring plasma specific protein for schizophrenia diagnosis and use thereof

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Embodiment Construction

[0023] The present invention will be further described in conjunction with the specific example of finding the diagnostic markers of schizophrenia based on the two-dimensional electrophoresis method. This example is only used to support the technical solution of the present invention, and is not intended to limit the present invention.

[0024] scope of invention.

[0025] The patients with schizophrenia were from the Shanghai Mental Health Center, and the CCMD-2-R (the second revision of the Chinese psychiatric classification scheme and diagnostic criteria) was used as the diagnostic standard. Matched control individuals were provided by the outpatient department of a hospital in Shanghai and were not diagnosed with schizophrenia. Blood was collected with the consent of the patient or the patient's family members, and an informed consent form approved by the Shanghai Human Genetic Resources Committee was signed.

[0026] The collected venous blood was centrifuged at 2000rpm×4℃...

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Abstract

This invention provides a method and usage for getting serum specificity protein for schizophrenia diagnosis, which utilizes a method of two-way gel electrophoresis to separate the under-test individual serum protein to get the expression volumes of alpha globin, alpha1 antitrypsin macroglobulin, serum amyloid p component, antifibrin-ferment III and vitamin D bindin to be taken as the reference basis for judging if a patient suffers from schizophrenia.

Description

technical field [0001] The invention relates to a method for obtaining six specific proteins in human plasma, and describes the application of the expression of these specific proteins in the diagnosis of schizophrenia. The present invention provides molecular biological indicators for the diagnosis of schizophrenia, which will effectively promote the prevention and treatment of the disease. The invention belongs to the technical field of biological detection. Background technique [0002] Schizophrenia is a common mental disease that seriously endangers human physical and mental health, and its incidence rate ranks first among all kinds of mental disorders. Epidemiological survey data show that the incidence of schizophrenia is about 0.5%-1% all over the world, and there are nearly 50 million schizophrenia patients in the world. Patients often have various obstacles in perception, thinking, emotion, behavior and incoordination of mental activities. Huge human resources a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N27/26G01N21/31G01N21/78
Inventor 贺林万春玲江蕾喇玉娟朱慧杨异凤冯国鄞
Owner SHANGHAI JIAO TONG UNIV
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