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Medicine for treating Parkinson's disease

A technology of Parkinson's disease and active ingredients, which is applied in the field of traditional Chinese medicine for the treatment of Parkinson's disease, can solve the problems of PD patients with increasing difficulties and central damage: end-of-dose phenomenon, on-off phenomenon, abnormal inactivity, sleep disorders, etc., to achieve Effects of improving dyskinesia, improving motor function, and reducing complications

Inactive Publication Date: 2007-06-06
THE FIRST PEOPLES HOSPITAL OF NANTONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most effective drug for the treatment of PD in internal medicine is dopa preparations, but the following types of problems are encountered in the treatment process of using dopa preparations: ①The curative effect attenuation problem in the treatment process of L-Dopa, usually 2 ~ 4 years, and has no certain relationship with the course of the disease sooner or later; ② Side effects during L-Dopa treatment: including peripheral damage: gastrointestinal symptoms, hypertension, positional hypotension, arrhythmia, etc.; central damage: End-of-dose phenomenon, on-off phenomenon, paradoxical inactivity, sleep disturbance, mental symptoms, etc.
Added a lot of difficulties to the treatment of PD patients with dopa preparations, and even had to stop the drug treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The raw materials in the following weight proportions are respectively made into granules according to the following methods, to obtain the medicine for the treatment of Parkinson's disease:

[0019] Cooked land 8% Mountain dogwood meat 9%

[0020] Red Ginseng 7% Raw Astragalus 23%

[0021] Salvia 16% Leech 12%

[0022] Dead Silkworm 13% Whole Scorpion 12%.

[0023] 1. The red ginseng of the above-mentioned weight components is extracted twice with water as a solvent, the first time adding a solvent of 10 times the amount of the medicinal material to extract for 1.5 hours, filtering, the medicinal residues continue to add a solvent of 8 times the amount to extract for 1 hour, filter, combine Twice the filtrate, concentrated under reduced pressure to clear paste, for later use;

[0024] ②The meat and Salvia miltiorrhiza were extracted twice with 75% ethanol as solvent. The first time was added with 8 times the amount of solvent for extraction for 1.5 hours, filtered, ...

Embodiment 2

[0028] The weight ratio of each raw material is:

[0029] Delicatessen 12% Mountain Dogwood 13%

[0030] Red Ginseng 5% Raw Astragalus 30%

[0031] Salvia 24% Leech 5%

[0032] Dead Silkworm 6% Whole Scorpion 5%. The rest are the same as in Example 1 to obtain the product.

Embodiment 3

[0034] The weight ratio of each raw material is:

[0035] Deli 15% Mountain Dogwood 6%

[0036] Red Ginseng 4% Raw Astragalus 17%

[0037] Salvia 30% Leech 10%

[0038] Dead Silkworm 10% Whole Scorpion 8%. The rest are the same as in Example 1 to obtain the product.

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Abstract

The invention provides a medicine for treating Parkinson's disease, which is prepared from prepared rhizome of rehmannia, pulp of dogwood fruit, red ginseng, raw astragalus root, root of red rooted saliva, leeches, silkworm, and scorpion.

Description

Technical field: [0001] The invention relates to a medicine, which is a traditional Chinese medicine for treating Parkinson's disease. Background technique: [0002] Parkinson's disease (PD) is a neurodegenerative disease common in middle-aged and elderly people. Its prevalence and incidence increase with age. The prevalence of different regions and ethnic groups in the world fluctuates from 31 to 307 / 100,000 population, the etiology of PD is still unknown. At present, it is believed that it may be related to the following factors: ① accelerated aging; ② individual susceptibility; ③ environmental toxicants; ④ infection and immunity; ⑤ abnormal oxidation reaction. Among them, the role of oxidative stress in the pathogenesis of PD has attracted the attention of many scholars. At present, the most effective medicine for PD in internal medicine is dopa preparations, but the following types of problems are encountered in the process of using dopa preparations: 1. The effect of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K36/53A61K36/481A61K36/40A61K36/258A61K35/64A61K35/62A61P25/16A61K35/646
Inventor 黄怀宇赵晓晖黄志东顾承志
Owner THE FIRST PEOPLES HOSPITAL OF NANTONG
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