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Chinese traditional medicine Tripterygium wilfordii and improving technique for attenuation and synergy of its extract

A technology of tripterygium wilfordii and extract is applied in the field of modification of traditional Chinese medicine tripterygium wilfordii and its extract, and achieves the effects of simple operation, low cost and reduced toxicity

Inactive Publication Date: 2007-07-11
杨更亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is still a vacancy in the domestic main technology in the modification of Tripterygium wilfordii for poison reduction and efficiency enhancement

Method used

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  • Chinese traditional medicine Tripterygium wilfordii and improving technique for attenuation and synergy of its extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 120g of Tripterygium wilfordii, soak it with 0.03N HCl solution, and place it in a refrigerator at 10°C for 48 hours at the same time, so that most of triptolide in the sample is converted into triptolide, and the conversion rate reaches more than 25%. After taking it out, extract it with chloroform three times, 300ml each time, wash the extract with water until it is neutral, and then wash it with anhydrous Na 2 SO 4 After drying and concentration under reduced pressure, 0.98 g of a concentrate was obtained.

Embodiment 2

[0026] Step 1: Weigh 650g of Tripterygium wilfordii, add 800ml of 95% ethanol, reflux extraction 3 times, each time for 6 hours, filter, combine the ethanol liquid, recover ethanol under reduced pressure, and obtain 12.0g of total component extract.

[0027] Step 2: Weigh 130g of Tripterygium wilfordii, add 300ml of ethyl acetate, reflux and extract 3 times, each time for 6 hours, filter, combine the ethyl acetate solution, recover ethyl acetate under reduced pressure, and obtain a leaching compound mainly of medium polar compounds. Cream 1.56g. Add 6.0 g of the extract obtained in the first step to 25 ml of ethyl acetate, ultrasonically extract 3 times for 45 minutes each time, filter, combine the ethyl acetate solution, and recover the ethyl acetate under reduced pressure to obtain 1.31 g of extract. After dissolving 1.56g of extract with a small amount of ethyl acetate, stir in 4.4g of neutral alumina, aluminum peroxide column, discard ethyl acetate: petroleum ether (1:9) e...

Embodiment 3

[0032] The first step: Tripterygium wilfordii 600g, add 700ml95% ethanol, method is the same as the first step of embodiment 2, obtains total composition extract 12.0g.

[0033]The second step: take tripterygium wilfordii 100g, add 250ml ethyl acetate, the method is the same as the second step of Example 2, and obtain mainly 1.24g of medium polar compound extract. 5.6 g of the extract obtained in the first step was added to 20 ml of ethyl acetate, and the method was the same as in the second step of Example 2 to obtain 1.16 g of extract. After dissolving 1.24g of extract with a small amount of ethyl acetate, stir in 4.0g of neutral alumina, aluminum peroxide column, discard ethyl acetate: petroleum ether (1:9) eluent 190ml, collect ethyl acetate: 400ml of petroleum ether (1:1) eluent was concentrated under reduced pressure to obtain sample A. After dissolving 1.16g of extract with a small amount of ethyl acetate, stir in 3.0g of neutral alumina, aluminum peroxide column, disc...

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Abstract

The invention discloses a modifying process of attenuation and synergy for Tripterygium wilfordii and its extract, wherein the procedure (1) comprises immersing Tripterygium wilfordii with acid solution, conversing Triptolidenol Triptonide into Tripchlo-rolide (II). While the procedure (2) comprises preparing concrete from Tripterygium wilfordii, then purifying Tripterygium wilfordii or its concrete, acid treating or immersing with acid solution.

Description

technical field [0001] The invention relates to methods for extracting, purifying and identifying natural medicines, in particular to a method for modifying traditional Chinese medicine Tripterygium wilfordii and its extracts. Background technique [0002] Triptergium wilfordii generally refers to the triptergium wilfordii Hook.f., which is produced in Zhejiang, Anhui, Hunan, Fujian and other provinces, mainly in the Yangtze River. Downstream areas; Kunming Mountain Begonia (T.hypoglaucum Hutch), produced in the Yangtze River Basin and Southwest; Northeast Tripterygium (T.regelii Spragnc et Takcda), also known as black vine, mainly produced in Northeast China and Japan. Tripterygium wilfordii was first recorded in "Shen Nong's Materia Medica", and it has been widely used clinically for many years to treat rheumatoid arthritis, chronic nephritis, hepatitis, thrombocytopenic purpura and various skin diseases. At present, research on anti-fertility, anti-tumor, and anti-reject...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/37A61P29/00A61P19/02A61P1/16A61P13/12A61P7/00A61P17/00A61P35/00
Inventor 杨更亮李保芝白洁陈义
Owner 杨更亮
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