Anti-sebum skin care cosmetic compositions containing branched esters

A technology of skin care cosmetics and compositions, applied in the direction of cosmetics, cosmetic preparations, drug combinations, etc.

Inactive Publication Date: 2002-06-12
UNILEVER NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Esterification of alcohols changes their

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] This example describes the synthesis of the following isotridecyl esters: butyrate, nonanoate, caprate, benzoate, and linoleate.

[0058] These esters are synthesized by alcoholysis of the corresponding acid chloride (e.g., butyryl chloride) and isotridecanol (Exxal 13).

[0059] Linoleyl chloride was purchased from Nu-Chek-Prep, Inc. The following acid chlorides were purchased from Aldrich: benzoyl chloride and butyryl chloride. The following acid chlorides are synthesized: salicylic chloride, nonanoyl chloride, decanoyl chloride.

[0060] To a clean, dry 250ml round bottom flask, add 1.0 equivalent of acid, 100ml of anhydrous dichloromethane and a few drops of pyridine. The flask is equipped with a stir bar, a liquid addition funnel and a nitrogen conduit. To this addition funnel was added 1.05 equivalent of thionyl chloride dissolved in about 20 ml of dichloromethane. Thionyl chloride solution was added dropwise to the reaction mixture at room temperature. After the addi...

Embodiment 2

[0067] This example tests the inhibition of sebum by different branched-chain acetates in vitro.

[0068] The Exxate® esters used in these examples were obtained from Exxon and are given as follows: Trade name Branched Exxate  600 methyl branched 1-pentanol acetate Exxate  700 Exxal  7's acetate, Exxal  7 is branched and linear isomerism

[0069] Body mixture, containing about 40% dimethylpentanol Exxate  800 Exxal  8 acetate, Exxal  8 is dimethylhexanol Exxate  900 Exxal Acetate of 9, Exxal  9 is dimethylheptanol Exxate  1000 Exxal  Acetate of 10, Exxal  10 is trimethylheptanol and

[0070] Dimethyloctanol Exxate  1200 Exxal  Acetate of 12, Exxal  12 is Trimethylnonanol Exxate  1300 Exxal  13 acetate, Exxal  13 is tetramethylnonanol and

[0071] Trimethyldecanol sebaceous gland cell detection method:

[0072] Secondary cultures of sebaceous gland cells obtained from adult males were grown in 48-well or 96-well tissue culture pl...

Embodiment 5

[0092] deal with

[0093] From the results in Table 5, it can be seen that the branched benzoate and linoleate are effective sebum inhibitors. When comparing the results in Table 5 with the results in Tables 1 and 2, it can be seen that linoleate and benzoate are superior to acetate, and linoleate is the most effective.

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PUM

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Abstract

Cosmetic skin care methods and compositions containing methyl-branched esters. The inventive compositions provide control of sebum secretion from sebocytes, improved oil control and improved skin feel, prevent shine and stickiness, while also. providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photoaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin.

Description

Invention field [0001] The present invention relates to a cosmetic skin care composition containing branched chain esters for controlling sebum / oil on human skin and improving or preventing the appearance of skin aging. Background of the invention [0002] Cosmetics that improve the appearance of the skin are increasingly favored by consumers. Consumers often seek to reduce or delay signs of aging or photo-aged skin (eg, fine lines or wrinkles) as well as signs of dry and sagging skin. Consumers are also looking for other effects besides anti-aging. [0003] An unfavorable skin condition that often occurs is "oily skin". This condition is usually caused by excessive sebum on the skin. Sebum is skin oil produced by sebaceous gland cells (cells of the sebaceous glands in the skin) and then secreted onto the surface of the skin. Oily skin is associated with the unfavorable appearance of shiny and unpleasant touch. Oily skin affects different age groups. There i...

Claims

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Application Information

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IPC IPC(8): A61K8/00A61K8/19A61K8/25A61K8/30A61K8/37A61K8/67A61Q19/00A61Q19/08
CPCA61Q19/00Y10S514/873Y10S514/846A61K8/37A61Q19/08A61K8/375A61P17/00A61K8/85
Inventor J·S·巴约尔S·S·哈比夫L·R·帕兰克
Owner UNILEVER NV
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