Composite eye-moistening liquid and its application

A composition and eye-moisturizing technology, applied in the direction of drug combination, medical preparations containing active ingredients, organic active ingredients, etc., can solve unsatisfactory problems, etc.

Inactive Publication Date: 2003-01-08
上海卫康光学眼镜有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this known solution for improving the comfort of contact lenses...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 composition solution of the present invention

[0023] Prepare according to the following proportions:

[0024] Sodium hyaluronate (MW=1.2×10 6 ) 0.5wt%

[0025] PVP (MW=3×10 4 ) 1.0wt%

[0026] Sodium Phosphate 0.8wt%

[0027] EDTA-2Na 0.1wt%

[0028] Polyhexamethylene biguanide 0.00015wt%

[0029] Sodium chloride 0.41wt%

[0030] Water added to 100wt%

[0031] Adjust the pH with appropriate amount of hydrochloric acid or sodium hydroxide

[0032] First heat 20wt% water to 40°C, gradually add HA, PVP and EDTA-2Na under stirring, after dissolving, cool to room temperature and then add polyhexamethylene biguanide, NaCl and sodium phosphate, add to 100wt% with pure water . Adjust the pH with HCl or NaOH, measure the osmotic pressure and pH value of the solution, the osmotic pressure is 292mOsm / KgH 2 O, the pH value is 7.23. The solution is then packaged for storage.

Embodiment 2

[0033] Example 2 Testing the comfort and safety of compositions with different molecular weights and different amounts of sodium hyaluronate

[0034] Solution A

Solution B

Solution C

Solution D

Sodium hyaluronate

(MW is 1.2 million)

0.5wt%

0.0001wt%

Sodium hyaluronate

(MW is 500,000)

0.5wt%

0.0001wt%

polyvinylpyrrolidone

(MW is 30,000)

1.2wt%

1.2wt%

1.2wt%

1.2wt%

sodium borate

0.8wt%

0.8wt%

0.8wt%

0.8wt%

EDTA-2Na

0.1wt%

0.1wt%

0.1wt%

0.1wt%

Sodium chloride

0.41wt%

0.41wt%

0.41wt%

0.41wt%

polyhexamethylene biguanide

0.00012wt%

0.00012wt%

0.00012wt%

0.00012wt%

water

Add to 100wt%

Add to 100wt%

Add to 100wt%

Add to 100wt%

[0035] The molecular weight (MW) of sodium hyaluronate (eye drop grade) currently available on the market is ...

Embodiment 3

[0041] Example 3 Testing the comfort and safety of compositions with different molecular weights and different amounts of polyvinylpyrrolidone

[0042] Solution E

[0043] Among them, PVP-K30 is a linear homopolymer with a molecular weight of about 30,000, provided by BASF, and cl-PVP3040 is a cross-linked homopolymer with an average molecular weight of 3×10 5 , provided by BASF Corporation. The above-mentioned four E-H solutions were prepared according to the steps of Example 1 with the proportioning described in Table 3, and the intrinsic viscosity was measured with an Ubbelohde viscometer. The viscosities of the four solutions were H>G>F>E.

[0044] The eye drops experiment was carried out according to the steps of Example 2, and the comparison groups were E to F, G to H, F to G, and E to G. The specific results are shown in Table 4:

[0045] group

[0046] It can be seen from the above results that the effect of cross-linked PVP3040 is much more sig...

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PUM

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Abstract

The present invention uses sodium hyaluronate and polyvinyl pyrrolidone together to produce synergistic action and prepare said invented eye-moistening solution composition which possesses the effects of moistening eye region, making artificial tears, raising exchange of tears and lubricating soft contact lens to raise wearing comfort.

Description

technical field [0001] The present invention relates to an eye lotion composition for wetting and lubricating contact lenses and artificial tears and its application. Background technique [0002] Contact lenses have become a substitute for glasses to correct vision defects, and are popular and loved by consumers because of their many advantages. Contact lenses widely used today are divided into two categories, one is a hard lens with methyl methacrylate as the main raw material; the other is a hydrogel or a Soft lenses. [0003] With hard contact lenses, there is a "pumping" action due to the pressure exerted by the upper eyelid on the upper part of the lens, which acts as a fulcrum. This pumping induces the desired exchange of tear fluid, thereby improving eye comfort. [0004] With soft contact lenses, however, this pumping does not exist (cf. Mandel, Contact Lens Practice, P 512, 1981), and therefore, tear exchange is reduced in the eyes of soft contact lens wearers. ...

Claims

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Application Information

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IPC IPC(8): A61K31/765A61P27/02
Inventor 陈奇
Owner 上海卫康光学眼镜有限公司
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