External used medicine for traumatic injury and preparation thereof
A technology for external use of medicines and bruises, which is applied to medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, etc., to achieve convenient use and good curative effect
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[0031] Experimental results: The drug of the present invention can significantly reduce the number of writhing reactions in mice caused by acetic acid, and the analgesic rate is 70%. There are significant differences between each dose group and the blank control group (P0.05). The experimental results show that the medicine of the invention has analgesic effect. Experimental example 2 Anti-inflammatory experiment of the drug of the present invention
[0032] 1. Experimental materials
[0033] 1. The spray of the drug of the present invention: Specification: 15ml / bottle, content: 0.24g crude drug / ml, the drug is formulated with 55% ethanol to (60%, 30% V / V) concentration, with 100%, 60%, At a concentration of 30%, mice in each dose group were coated with the same volume of 0.1ml / 20g (body weight), and rats in each dose group were coated with the same volume of 0.5ml / 100g (body weight).
[0034] 2. Muscle-strengthening liquid: produced by Guiyang Duyun Pharmaceutical Factory, batch n...
Example Embodiment
[0060] 4. Conclusion The above experimental results show that the drug of the present invention can inhibit the inflammatory reaction of mice ears caused by xylene, which is different from the control group, and can obviously inhibit the joint inflammation of the ankle joint caused by cg, which is more effective than the control group. The difference indicates that the drug of the present invention has an anti-inflammatory effect. Experimental Example 3 Clinical observation of the therapeutic effect of the medicine of the present invention on 390 cases of traumatic pain and arthralgia
[0061] 1. Grouping situation:
[0062] According to the different order of treatment, the patients were divided into two groups according to the principle of randomization. The ratio of the treatment group and the control group was 2:1. Adopt outpatient cases and inpatient cases, and outpatient cases strictly control variable factors. The specific groups are as follows:
[0063] 1. In the drug grou...
Example Embodiment
[0042] The fourth group, the medium-dose group of the drug of the present invention, is coated with the concentration of the drug of the present invention (60% V / V)
[0085] Observe the anti-inflammatory effect of the drug of the present invention by retrograde electrical stimulation of the saphenous nerve in rats to cause neuroinflammation; measure the amount of skin Evans blue exudation (Evans blue is a product of German Serva), further confirming that the model is an effective drug for screening neuroinflammation This shows that the analgesic and swelling effect of the drug of the present invention is closely related to the inhibition of neuroinflammation and the reduction of capillary plasma protein exudation, and it can be widely used in the research of external anti-inflammatory and analgesic. Experimental Example 5 Clinical experiment on the treatment of traumatic pain with the medicine of the present invention
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