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External used medicine for traumatic injury and preparation thereof

A technology for external use of medicines and bruises, which is applied to medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, etc., to achieve convenient use and good curative effect

Inactive Publication Date: 2003-09-03
成都利尔药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although all can achieve a certain curative effect, there are still problems such as how to further improve the curative effect and reduce side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 2

[0031] Experimental results: the medicine of the present invention can significantly reduce the number of writhing reactions in mice caused by acetic acid, and the analgesic rate is 70%. There was no difference compared with the control group (P>0.05). Experimental results show that the medicine of the present invention has analgesic effect. Experimental Example 2 Drug anti-inflammatory experiment of the present invention

[0032] 1. Experimental materials

[0033] 1, the spray of medicine of the present invention: specification: 15ml / bottle, content: 0.24g crude drug / ml, medicine is mixed with (60%, 30%V / V) concentration with 55% ethanol, with 100%, 60%, At 30% concentration, mice in each dosage group were coated with the same volume of 0.1ml / 20g (body weight), and rats in each dosage group were coated with the same volume of 0.5ml / 100g (body weight).

[0034] 2. Tendon-injured bone-setting liquid: produced by Guiyang Duyun Pharmaceutical Factory, batch number: 970901, speci...

experiment example 3

[0060] Four, conclusion shows by above-mentioned experimental result: the mouse ear inflammation reaction that the medicine of the present invention can suppress xylene causes, compares difference with matched group, and can obviously suppress uncle's ankle joint inflammation reaction caused by cg, compares with matched group. The difference shows that the medicine of the present invention has anti-inflammatory effect. Experimental example 3 The clinical observation of medicine of the present invention to 390 traumatic pains and arthralgia treatment effect

[0061] 1. Grouping situation:

[0062] According to the order of visits, the patients were randomly divided into two groups, and the ratio of the treatment group to the control group was 2:1. Outpatient cases and inpatient cases were used, and variable factors were strictly controlled in outpatient cases. The specific groups are as follows:

[0063] 1, 390 examples of the drug group of the present invention, 200 example...

experiment example 4

[0085] Cause neuroinflammation by retrograde electrical stimulation of rat saphenous nerve and observe the anti-inflammatory effect of the medicine of the present invention; measure skin Evans blue exudation amount (Evans blue is the product of Serva Company of Germany), further confirm that this model is to screen the effective drug to neuroinflammation This shows that the analgesic and detumescent effect of the drug of the present invention is closely related to the inhibition of neuroinflammation and the reduction of capillary plasma protein exudation, and can be widely used in the research of external anti-inflammatory and analgesic etc. Experimental Example 5 Clinical Experiment of Drug Treatment of Traumatic Pain of the Present Invention

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PUM

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Abstract

An exterior-applied Chinese medicine for treating bone fracture, dislocation, joint sprain, hyperosteogeny, rheumatic arthritis, and soft tissue injury is prepared from 44 Chinese-medicinal materials including notoginseng, Sichuan aconite root, Chuan-xiong rhizome, myrrh, etc. Its advantages are high curative effect and high safety.

Description

technical field [0001] The invention relates to an externally used medicine for treating bruises. Specifically, it is a Chinese patent medicine prepared from traditional Chinese medicine, and the invention also relates to a preparation method and application of the medicine. Background technique [0002] Fractures, dislocations, joint sprains, hyperosteogeny, rheumatoid arthritis, and soft tissue injuries are common clinical symptoms. Mostly due to trauma, local meridian Qi and blood damage, circulatory dysfunction, or external evils such as wind, cold, damp, etc., when the body's righteousness is weak, invade the skin, stay in the tendons and focus on joints, resulting in blockage of tendons and collaterals , the flow of qi, blood and body fluid is not smooth, "blockage leads to pain", "loss of nourishment leads to numbness", tendons and arteries are disused, and local swelling, pain, and dysfunction are formed. The treatment of this disease, method ...

Claims

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Application Information

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IPC IPC(8): A61P19/00A61P19/08A61P21/00A61P29/00
Inventor 陈云华李军刘艳
Owner 成都利尔药业有限公司
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