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Chinese medicine for treating vascular dementia and its prepn

A technology of vascular dementia and traditional Chinese medicine, which is applied in the direction of medical formulas, cardiovascular system diseases, medical preparations containing active ingredients, etc., and can solve problems such as low efficiency, high cost, and large toxic and side effects

Inactive Publication Date: 2003-11-05
ZHONGJING WANXI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These treatments can improve the memory and cognitive functions of dementia patients to some extent, but the efficiency is not high, the side effects are large, and they must be taken all year round, and the cost is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] detailed description Embodiment 1: the present invention treats the clinical curative effect of the Chinese medicine of vascular component dementia effect

[0044] The 100:100 example phase II clinical study carried out in several hospitals such as the Affiliated Hospital of Changchun College of Traditional Chinese Medicine and the Chinese medicine granules made by the prescription of the present invention and the French Servier Company, the specific content and results are reported as follows: Purpose

[0045] Through clinical trials, observe the efficacy of this granule in treating vascular dementia with hyperactivity of liver-yang type and make a preliminary evaluation of its safety on the human body, and compare and observe with known effective drugs, and recommend the clinical dosage. normal information

[0046] by x 2 Statistics and t-test statistics, the following aspects: outpatient and inpatient cases; gender distribution of men and women; age distribution; ...

Embodiment 2

[0100] Through clinical trials, the granules and known drugs have achieved basically the same curative effect in terms of cognitive function, behavioral ability, memory, calculation and orientation, and are significantly better than both in terms of TCM syndromes. , and can significantly improve abnormal indicators of hemorheology and blood lipids. According to statistics, the total effective rate of the granule is 52.38%, and that of the control group is 52.50%, and there is no significant difference between the two groups; in terms of TCM syndrome, the total effective rate of the granule is 80.95%, and that of the control group is 80.95%. was 57.50%, and the treatment group was significantly better than the control group; in terms of hemorheology, both drugs could significantly improve whole blood viscosity, low shear, plasma viscosity, and hematocrit (P Embodiment 2: the preparation method of the Chinese medicine granule of the present invention treatment vascular dementia ...

Embodiment 3

[0108] Take lactose powder, β-cyclodextrin and the fine drug powder obtained by the above spray drying, mix them in a ratio of 2:0.5:5, and then add 0.5% of the flavoring agent stevioside and 0.2% of magnesium stearate , mixed, and granulated by dry extrusion with 70kg pressure to make 1000g of finished product, three times a day, taking 5g each time. Embodiment 3: the preparation method of the Chinese medicine capsule of the present invention treatment vascular dementia

[0109] Weigh raw materials according to the following ratio (g)

[0110] Gastrodia elata 550 Uncaria 550 Stone Cassia 550 Eucommia 550

[0111] Sangjisheng 550 Fushen 550 Polygonum vine 550 Huaihua 280

[0112] Gardenia 320 Scutellaria baicalensis 300 Sichuan Achyranthes bidentata 450 Motherwort 550

[0113] First get Uncaria, Sangji, Motherwort, Polygonum multiflorum plus 5 times (w / v) 78% ethanol to reflux and extract twice, each time reflux for 1.5 hours, combine the extracts, and reduce them under th...

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Abstract

The Chinese medicine for treating vascular dementia is prepared with 12 kinds of Chinese medicinal materials including gastrodia tuber, hooked uncaria, abalone shell, eucommia bark, parasitic loranthus, etc. and through extracting the effective components, and preparing the extractives into granule, capsule, tablet and other proper forms. The Chinese medicine for treating vascular dementia has the functions of calming the liver, suppressing the sthenic Yang, and invigorating liver and kidney and thus has excellent curative effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparation, and relates to a traditional Chinese medicine for treating vascular dementia and a preparation method thereof. Background technique [0002] Vascular dementia is a dementia syndrome caused by vascular lesions. It is clinically characterized by memory and other cognitive dysfunction, such as judgment, orientation, calculation, and comprehensive comprehension, and the above-mentioned manifestations change in a step-like manner with repeated strokes. as a feature. Acute onset, emotional fluctuations, irritability, and personality disorder in the late stage. It is often accompanied by neurological symptoms and signs, such as hemiplegia, aphasia, apraxia, agnosia, etc. Most of them have a history of hypertension. The so-called stroke dementia in traditional Chinese medicine belongs to this category. [0003] Due to impairment of memory and other cognitive functions, the reduc...

Claims

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Application Information

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IPC IPC(8): A61P9/10A61P25/28
Inventor 孙耀志刘显锋李长春高松
Owner ZHONGJING WANXI PHARMA CO LTD
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