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Protein microarray surface plasma resonance imaging detection system and detection method

A surface plasma and detection system technology, applied in biochemical equipment and methods, microbial determination/inspection, biological testing, etc. Effect

Inactive Publication Date: 2003-12-10
TSINGHUA UNIV
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  • Abstract
  • Description
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Problems solved by technology

This structure can achieve high throughput, but it has high technical requirements for signal acquisition and low precision, so it is difficult to popularize

Method used

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  • Protein microarray surface plasma resonance imaging detection system and detection method
  • Protein microarray surface plasma resonance imaging detection system and detection method
  • Protein microarray surface plasma resonance imaging detection system and detection method

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Embodiment Construction

[0021] The protein microarray SPR imaging detection system and detection method of the present invention will be described below with reference to the accompanying drawings.

[0022] Such as Figure 4 As shown, the protein microarray SPR imaging detection system of the present invention includes a surface plasmon resonance microarray protein sensor, an incident arm, a reflection arm and a signal processing unit, and the surface plasmon resonance microarray protein sensor includes a prism 25, placed in the prism The microarray chip 27 on the 25 bottom surface and the sample pool 29 placed under the chip; the refractive index oil layer 26 is coated between the prism 25 and the microarray chip 27; the incident arm is located at the surface plasmon resonance microarray protein sensor One side includes semiconductor laser 19, collimator 21 with built-in pinhole filter 20, polarizer 22, attenuator 23 and rectangular diaphragm 24 in sequence; The other side of microarray protein sen...

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Abstract

The present invention provides a protein micro-array surface plasma resonance imaging detection system and its detection method. Said system includes surface plasma resonance micro-array protein sensor, incident arm, reflecting arm and signal processing unit, the described sensor includes prism, micro-array chip and sample cell, between prism and micro-array chip a refractivity oil layer is coated, the incident arm is positioned at one side of the sensor, successively includes semiconductor laser, collimator, polarizer, attenuator and reactangular light diaphragm, the reflecting arm is positioned at another side of the sensor, and successively includes lens and CCD receiver, and signal processing unit includes signal processing circuit and computer.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a real-time detection method and special equipment for realizing high-throughput detection of protein-protein, ligand-receptor, effector-protein and other interactions. Background technique [0002] The Human Genome Project, that is, the determination of the structure of a complete set of human genes has been basically completed, followed by a dynamic and holistic understanding of the nature, panorama and Its laws, understanding of the occurrence and development of diseases, discovery and development of new drugs. The sequence structure of the genome is static and relatively stable; proteins, on the other hand, are dynamic and affected by time and space. Research is not only faced with huge data, but also dynamic information, so it is urgent to realize high-throughput real-time detection. The biomolecular interaction detection method based on the surface plasmon resonan...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68G01N21/27G01N33/543G01N33/68G02B5/04
CPCG01N21/553G01N21/253
Inventor 余兴龙王鼎新魏星王东生欧阳溅华赵新生
Owner TSINGHUA UNIV
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