Antihistamines for treatment of nasal congestion and nasal obstruction

A technology of antihistamines and decongestants, applied in the direction of anti-inflammatory agents, drug combinations, non-central analgesics, etc.

Inactive Publication Date: 2004-08-04
SCHERING AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These and other unwanted side effects may cause patients with hyperemia associated with allergic disease to avoid or discontinue treatment with products containing pseudoephedrine

Method used

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Examples

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Comparison scheme
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Embodiment Construction

[0011] The phrase "allergic and inflammatory conditions of the airflow passages" refers to those allergic and inflammatory diseases and conditions found in the upper and lower airways from the nose to the lungs. Typical allergic and inflammatory diseases of the upper and lower airways include seasonal and common allergic rhinitis, non-allergic rhinitis, asthma (both allergic and non-allergic), sinusitis, and colds .

[0012] The term "congestion" refers to an obstruction with reduced nasal cavity diameter and increased nasal airflow resistance, thus reducing obstruction, non-ventilation or blockage of the upper airways from the nose to the lungs and / or constriction of the lower airways, including severe nasal congestion and congestion.

[0013] The term "nasal congestion" refers to a subject with congestion who suffers from moderate to severe nasal congestion and nasal airflow obstruction, typically with minor rhinorrhea. For example, at the initial visit, the subject should...

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PUM

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Abstract

The present invention relates to the use of desloratadine and / or other antihistamines in the treatment and / or prevention of severe nasal congestion and / or nasal congestion associated with allergic and inflammatory diseases of the upper and lower airways of humans .

Description

field of invention [0001] The present invention relates to the use of desloratadine and / or other antihistamines in the treatment and / or prevention of nasal congestion and / or nasal congestion defined as those associated with allergies and Symptoms of nasal airflow limitation associated with inflammatory conditions such as seasonal allergic rhinitis. Background of the invention [0002] US Patent 4659716 discloses desloratadine, a nonsedating antihistamine useful in the treatment of allergic reactions in animals, including humans. US Patent 5695997 discloses pharmaceutical compositions comprising desloratadine and methods of using desloratadine for the treatment and prevention of disease conditions such as allergic rhinitis. [0003] Severe nasal congestion / stuffing and / or blockage is a chronic symptom in patients with allergic diseases such as allergic rhinitis. However, existing antihistamines are not yet effective in treating severe nasal congestion and congestion / stiffne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/137A61K31/445A61K31/454A61K31/4545A61K31/495A61K31/55A61P11/02A61P11/06A61P27/16A61P29/00A61P37/08A61P43/00
CPCA61K31/495A61K31/137A61K31/454A61K31/4545A61K31/445A61K31/55A61P11/02A61P11/06A61P27/16A61P29/00A61P37/08A61P43/00A61K2300/00
Inventor L·M·萨尔蒙P·罗哈尼R·R·罗尔伯
Owner SCHERING AG
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