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Sophocarpidine gel preparation and its process

A technology of total alkaloids and gel preparations, applied in pharmaceutical formulations, antifungal agents, topical antibacterial agents, etc., can solve the problems of greasy feeling, poor mucoadhesion, low bioavailability, etc., and achieve proper consistency. , Strong adhesion, long residence time

Inactive Publication Date: 2004-08-18
上海海天医药科技开发有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantages of suppositories are that they are easy to dissolve and flow out, have a greasy feeling, and have poor adhesion to mucous membranes and low bioavailability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Remove the mud, sand and other impurities from the Sophora flavescens that meets the requirements of the Chinese Pharmacopoeia, and then pulverize it for use.

[0027] The crushed Sophora flavescens was percolated with 0.2% hydrochloric acid, the ratio of Sophora flavescens to hydrochloric acid was 1:10, and the percolation liquid was collected.

[0028] The pH value of the obtained percolation liquid was adjusted to 7 with ammonia water, and a precipitate was separated out at this time. This precipitate was filtered off, and the filtrate was collected.

[0029] Make the resulting filtrate pass through 110 type cation exchange resin with the load of the ratio of 1: 1 with medicinal material amount g / resin ml, then use 5% ammoniacal liquor to wash resin with the elution ratio of 5: 1 (elution volume / resin volume) The adsorbate was eluted, and the eluate was collected.

[0030] Ammonia is recovered, and the eluent is concentrated to dryness to obtain total alkaloids of ...

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PUM

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Abstract

The total matrine gel preparation contains total matrine in 3-5 wt% and Carbocromen in 0.5-1.5 wt%. The present invention also provides the preparation of the gel preparation including the steps of extracting total matrine with type-110 cationic exchange resin; forming gel with Carbocromen as adjuvant; dissolving total matrine in ethanol and propylene glycol to form solution and adding the solution into the gel to form the total matrine gel preparation. The gel preparation has the advantages of powerful adhesional force to mucous membrane and thus prolonged detention time in vagina and raised curative effect.

Description

technical field [0001] The invention relates to a gel preparation of total alkaloids of matrine and a preparation method of the gel preparation. Background technique [0002] Matrine total alkaloids are used to treat women's mycotic, bacterial, and trichomonal vaginitis, and cervical erosion is known. The known dosage form of the total alkaloid preparation of matrine for the treatment of the above-mentioned gynecological diseases is a suppository. However, the disadvantages of suppositories are that they are easy to dissolve and flow out, have a greasy feeling, and have poor adhesion to mucous membranes and low bioavailability. Therefore the prior art expects to develop new dosage forms of the total alkaloids of matrine preparations that can overcome the above shortcomings. [0003] In addition, in order to optimize the extraction process of matrine total alkaloids and find suitable excipients to prepare new dosage forms of matrine total alkaloids preparations, it is neces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4375A61P15/00A61P31/02A61P31/10A61P33/02
Inventor 于喜水王有志马桔云
Owner 上海海天医药科技开发有限公司
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