Sophocarpidine gel preparation and its process

Abstract

The total matrine gel preparation contains total matrine in 3-5 wt% and Carbocromen in 0.5-1.5 wt%. The present invention also provides the preparation of the gel preparation including the steps of extracting total matrine with type-110 cationic exchange resin; forming gel with Carbocromen as adjuvant; dissolving total matrine in ethanol and propylene glycol to form solution and adding the solution into the gel to form the total matrine gel preparation. The gel preparation has the advantages of powerful adhesional force to mucous membrane and thus prolonged detention time in vagina and raised curative effect.

Description

technical field

[0001] The invention relates to a gel preparation of total alkaloids of matrine and a preparation method of the gel preparation. Background technique

[0002] Matrine total alkaloids are used to treat women's mycotic, bacterial, and trichomonal vaginitis, and cervical erosion is known. The known dosage form of the total alkaloid preparation of matrine for the treatment of the above-mentioned gynecological diseases is a suppository. However, the disadvantages of suppositories are that they are easy to dissolve and flow out, have a greasy feeling, and have poor adhesion to mucous membranes and low bioavailability. Therefore the prior art expects to develop new dosage forms of the total alkaloids of matrine preparations that can overcome the above shortcomings.

[0003] In addition, in order to optimize the extraction process of matrine total alkaloids and find suitable excipients to prepare new dosage forms of matrine total alkaloids preparations, it is neces...