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Fibraurea stem element jelly glue preparations and preparation technique thereof

A gel preparation, the technology of palmatine, applied in the field of palmatine gel preparation and its preparation, can solve the problems of inconvenient medication, foreign body sensation, easy to flow out of the body, etc., and achieve the effect of easy storage

Inactive Publication Date: 2008-08-27
JINAN TIANCHOU PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, like other gynecological suppositories, padatine vaginal suppositories have a foreign body sensation when taking medicine, and the suppository matrix melts at body temperature, which is easy to flow out of the body and is inconvenient to use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Palmatine 2.5g

[0021] Sodium alginate 20.0g

[0022] Citric acid 0.3g

[0023] Sodium Benzoate 1.0g

[0024]

[0025] Add distilled water to make 1000g

[0026] Preparation method: (1) Weigh 1.0 g of sodium benzoate as a preservative and 0.3 g of citric acid as a pH regulator, add distilled water for stirring, and stop heating after heating to 70-80°C.

[0027] (2) Slowly add 2.5g of palmatine and stir until dissolved.

[0028] (3) Slowly add 20.0 g of gel matrix sodium alginate and stir until completely dispersed.

[0029] (4) Add distilled water to the full amount, continue to stir, and naturally cool to room temperature to obtain a transparent gel, which is packaged in an applicator.

Embodiment 2

[0031] Palmatine 5g

[0032] Hydroxypropyl methylcellulose (molecular weight 4000) 25.0g

[0033] Citric acid 0.3g

[0034] Ethylparaben 1.0g

[0035]

[0036] Add distilled water to make 1000g

[0037] Preparation method: (1) Weigh 1.0 g of preservative ethyl paraben and 0.3 g of citric acid as pH regulator, add distilled water and stir, heat to 70-80°C and stop heating.

[0038] (2) Slowly add 5.0 g of palmatine and stir until dissolved.

[0039] (3) Slowly add 25.0 g of gel matrix hydroxypropyl methylcellulose (molecular weight: 4000), and stir until completely dispersed.

[0040] (4) Add distilled water to the full amount, continue to stir, and naturally cool to room temperature to obtain a transparent gel, which is packaged in an applicator.

Embodiment 3

[0042] Palmatine 20.0g

[0043] Carbomer 940 15.0g

[0044] Ammonia 5.0g

[0045] Glycerin 100g

[0046] Methylparaben 1.0g

[0047]

[0048] Add distilled water to make 1000g

[0049] Preparation method: (1) Weigh 1.0g of preservative methyl paraben, add distilled water to stir, stop heating after heating to 70-80°C; slowly add 20.0g of palmatine, stir until dissolved; slowly add condensate Gum base Carbomer 940 15.0g, after fully dissolving, add 5.0g of ammonia water as a pH regulator, and stir evenly. (Or weigh 1.0g of methylparaben, add an appropriate amount of distilled water, slowly add 20.0g of patinol, and stir until dissolved; take 15.0g of gel matrix Carbomer 940 and spread it on the surface of the solution, and let it sit overnight to fully swell Finally, add 5.0 g of ammonia water as a pH regulator, and start stirring at the same time, and stir evenly.)

[0050] (2) Add 100 g of glycerin, add distilled water to...

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PUM

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Abstract

A fibrauretine gel preparation and a preparation method thereof are provided. The preparation contains 0.25-5wt% of fibrauretine, 0.5-5wt% of gel matrix, 0.01-1wt% of pH regulator, 0.05-0.15wt% of antiseptics and distilled water in balance. The preparation method doesn't use any stabilizer and employs heating process to completely swell the gel substrate during a short period of time. The production cycle is short and suitable for industrialized production. The fibrauretine gel has uniform and fine texture and good effect of coupling and hydration to mucosa, and also has the advantages of remarkable curative effect, convenient adminstraiton, long retention time in vagina, long-lasting action, complete release of active components, no foreign body sensation of vagina, no damage to vagina, no deformation, storage stability and no contamination to clothing.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a method thereof, in particular to a palmatine gel preparation and a preparation process thereof. Background technique [0002] The chemical name of palmitine hydrochloride is palmitine hydrochloride, and its molecular formula is C21H21NO4·HCl·3H2O. It is an effective anti-infection drug, has obvious antibacterial effect on Gram-positive and negative bacteria, and has obvious inhibitory effect on various fungi, and has different degrees of inhibitory effect on mycoplasma, chlamydia and mold. Palmatine is widely used in clinical practice. Gynecology is mainly used in acute and chronic adnexitis, acute and chronic pelvic inflammatory disease, acute and chronic cervicitis, acute and chronic endometritis, vulvitis, acute and chronic vaginitis, fungal vaginitis, postpartum infection Wait. [0003] According to the pharmacological effects of palmatine, it has a unique role and effect in the treatmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4375A61P31/04
Inventor 徐光奇
Owner JINAN TIANCHOU PHARMA TECH
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