Cefonicid sodium antibacterial composition

A technology of cefonicil and lactamase antibiotics, applied in the direction of antibacterial drugs, organic active ingredients, medical preparations containing active ingredients, etc., to achieve strong antibacterial effect and wide antibacterial spectrum

Inactive Publication Date: 2004-08-18
SHENZHEN SALUBRIS PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no reports on the market and clinical application of cefnixime and its salts, sulbactam and its salts, or tazobactam and its salts as new drugs at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: Preparation of cefnixin sodium and sulbactam sodium compound preparation

[0014] Mix 0.5 g of cefnixime sodium sterile powder and 1 g of sulbactam sodium sterile powder, and operate according to the known powder injection or freeze-dried powder injection process.

Embodiment 2

[0015] Embodiment 2: Preparation of cefnixin sodium and sulbactam sodium compound preparation

[0016] Mix 0.5 g of cefnixime sodium sterile powder and 0.5 g of sulbactam sodium sterile powder, and operate according to the known powder injection or freeze-dried powder injection process.

Embodiment 3

[0017] Embodiment 3: prepare the compound preparation of cefnicillin potassium and sulbactam sodium

[0018] Mix 0.5 g of cefnicillin potassium sterile powder and 0.25 g of sulbactam sodium sterile powder, and operate according to the known powder injection or freeze-dried powder injection process.

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PUM

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Abstract

The present invention discloses one kind of compound beta-lactamase resisting antibiotic preparation, and is especially compound preparation comprising Cefonicid and its salt and Sulbactam and its salt or Tazolbactum and its salt in the weight ratio of 0.5-10. The weight ratio between Cefonicid and its salt and Sulbactam and its salt is 0.5-6, preferably 1, and weight ratio between Cefonicid and its salt and Tazolbactum and its salt is 1-6, preferably 2. Compared with Cefonicid, the present invention has ever wide antibiotic spectrum and ever strong antibiotic effect.

Description

technical field [0001] The invention relates to an anti-beta-lactamase antibiotic compound preparation, in particular to a compound preparation composed of cefanixime and its salt, sulbactam and its salt or tazobactam and its salt. Background technique [0002] Cephalosporin antibiotics have been widely used clinically and played a positive role in human health. At the same time, due to the long-term and extensive clinical use, the problem of bacterial resistance to cephalosporin antibiotics is becoming more and more serious. The main mechanism of bacterial resistance to cephalosporin antibiotics is the production of specific β-lactamases (β-lactmases) to decompose drugs, including chromosome-mediated type I cephalosporinases and plasmid-mediated extended-spectrum β-lactamase. In order to overcome the clinical drug-resistant infection caused by β-lactamase-producing bacteria, it is of great clinical significance to develop compound preparations of cephalosporin antibiotics...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545A61P31/04
Inventor 叶澄海
Owner SHENZHEN SALUBRIS PHARMA CO LTD
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