Biomolecule with therapeutic tumour action and its use

Abstract

The invention is a biomolecule curing tumours, its character: in a special sequence, it is a dichain RNA molecule with 23 basic groups. Its molecular structure contains adenine nucleotide A, guanosine G, cytidine C and uridine U. Its beneficial effects: 1, obvious effect of prohibiting tumour growth and high selectivity, able to overcome poisonous side effect of quinoline drug; 2, good stability; 3, effect amplification; 4, easy to prepare. It can be used to prepare clinical antitumor drug, where the drug form is any one of water solution injection, liposome soliquoid injection and latex.

Description

technical field The present invention relates to the field of biomedicine, and more specifically, relates to biomolecules capable of treating tumors and their application. Background technique Tumor has become one of the most serious diseases that endanger human health globally. Due to the complexity of the causes of tumors, effective prevention cannot be carried out; at the same time, due to the particularity of tumor growth, it is difficult to diagnose early. Therefore, the treatment of neoplastic diseases mainly depends on clinical treatment. However, most of the current clinical drug treatments do not have obvious selectivity, and they also have obvious toxic side effects on normal cells. Therefore, the development of anti-tumor drugs with low toxicity, high selectivity and high effectiveness is the most urgent task in the field of medical biology today. With the deepening understanding of the molecular mechanism of tumor development, some molecules with higher spec...

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Problems solved by technology

The present inventors have carried out in-depth research in order to achieve the above object, and found that a double-stranded RNA molecule (structure shown in Figure 1) with a length of 23 base pairs in a specific order has a clear tumor-inhibiting effect, And the selectivity of its action is high, can overcome the toxic and side effects that quinolines exist to a large extent; Due to the disadvantages of poor stability and weak effect due to easy degradation, its tumor inhibitory effect is significantly higher than that of antisense nucleic acid

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