Pteridine derivatives with nitric oxide synthase inhibitor function

A compound, pteridine technology, applied in the field of pteridine derivatives, can solve the problem of lack of NOS isomerase inhibitory selectivity
CN1546491AInactive Publication Date: 2004-11-17CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2004-11-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates a novel pteridine derivative with formula (I), which is a NO synthetase, in particular the suppressant for evoked type NO synthetase, which can be used in the prevention and treatment of diseases caused by NO level rise.
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Description

technical field

[0001] The present invention relates to the design and synthesis of pteridine derivatives capable of controlling excessive production of nitric oxide free radicals (NO·, abbreviated as NO) in the body, especially pteridine derivatives with the effect of inducible NO synthase inhibitors. Medicines for preventing and treating diseases mediated by elevated NO levels in the body can be prepared.

[0002] This invention research work was funded by the National Natural Science Foundation of China (Project No. 39870822). Background of the invention

[0003] NO is a bioactive molecule with low molecular weight and hydrophobic properties, which can freely pass through the cell membrane and act on target molecules in the cell. Theoretically, NO can reach any part of the cell and tissue, so it can regulate various cell functions and Produce a wide range of biological effects. NO is produced by endogenous nitric oxide synthase (NO Synthase, abbreviated as NOS). NOS use...

Claims

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