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Paeonoside injection and its preparation method and use

A technology of paeoniflorin and injection, which is applied in the field of paeoniflorin injection and its preparation and application, can solve the problems that the treatment cannot achieve the expected effect, affect clinical application, poor absorption, etc., and achieve the purpose of resisting acute myocardial ischemia, inhibiting platelet aggregation, The effect of high bioavailability

Inactive Publication Date: 2004-12-22
昆明同持医药研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the ester bond in the molecular structure of paeoniflorin, it is relatively stable in the pH range of 2 to 6, but it will decompose under alkaline conditions.
The substance, although stable in the stomach, is poorly absorbed in the stomach; it breaks down due to the alkaline environment of the intestinal juices
Thereby this substance is used for the treatment of disease with oral preparation and can not reach expected effect, has influenced clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Weigh 50g of paeoniflorin and 20g of mannitol, add 1500ml of water for injection to dissolve, adjust the pH to 4, keep warm at 40°C for 20 minutes, cool to room temperature, add water for injection to dilute to 5000ml, and store the filtrate at 0-5°C Stand for 24 hours, filter through a 0.45 μm microporous membrane; filter through a 0.1 μm microporous membrane, potting (5ml / bottle), sterilize, and pack.

Embodiment 2

[0050]Weigh 50g of paeoniflorin, 10g of mannitol and glucose, add 1500ml of water for injection, adjust the pH to 5, dissolve, keep warm at 40°C for 20 minutes, cool, and filter through a 0.45μm microporous membrane; the filtrate is at 0-5°C Stand for 24 hours, dilute to 5000ml with water for injection, filter with 0.1μm microporous membrane, ultrafiltration membrane (molecular weight cut-off 10,000), potting (5ml / bottle), freeze-dry, and pack.

Embodiment 3

[0052] Weigh 50g of paeoniflorin and 20g of mannitol, add 2500ml of water for injection to dissolve, incubate at 40°C for 20 minutes, cool, filter with a 0.45μm microporous membrane, 0.2μm microporous membrane, and filter the filtrate at 0-5 Place at ℃ for 24 hours, dilute to 5000ml with water for injection, filter with 0.1μm microporous membrane, adjust the pH to 5, filter with ultrafiltration membrane (molecular weight cut-off 6000), potting (5ml / bottle), freeze-dry, pack, ready to serve .

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PUM

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Abstract

A paeoniflorin injection in the form of liquid or powder for preventing and treating coronary heart disease and thrombosis is prepared from paeoniflorin and medical auxiliary through dissolving, regulating pH value, keeping the tempat 30-60 deg.C for 10-30 min, cooling, filtering, laying aside at 0-5 deg.C for 1-48 hr, filtering to obtain liquid injection, freeze drying and sterilizing.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and its preparation method and application. Background technique [0002] Paeoniflorin, also known as paeoniflorin, has the functions of dilating coronary arteries, increasing coronary flow, resisting acute myocardial ischemia, inhibiting platelet aggregation and lowering blood pressure. Therefore, it can be used clinically for the treatment of coronary heart disease. However, due to the ester bond in the molecular structure of paeoniflorin, it is relatively stable in the pH range of 2 to 6, but will decompose under alkaline conditions. Although stable in the stomach, the substance is poorly absorbed in the stomach; it breaks down due to the alkaline environment of the intestinal juices. Thereby this substance can not reach expected effect with oral preparation for the treatment of disease, has influenced clinical application. This is an urgent technical problem to be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7048A61P7/02A61P9/10
Inventor 周春香
Owner 昆明同持医药研究有限公司
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