Gatifloxacin gels foreye and its preparing method

A technology of gatifloxacin and gel, which is applied in the field of gatifloxacin ophthalmic gel and its preparation, can solve the problems that there is no report on the research of GFLX ophthalmic gel preparation, and achieve prolonging the dosing interval, high viscosity, The effect of improving medication adherence

Inactive Publication Date: 2005-01-12
深圳市华晖生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ophthalmic gels of drugs such as tropicamide, pilocarpine, chloramphenicol and betamethasone have been developed and applied abroad, but there is no report on the research of GFLX ophthalmic gel preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment one. Gatifloxacin eye gel is made of the following medicines in weight percentage:

[0026] Gatifloxacin 0.3%

[0027] Propylene Glycol 10%

[0028] Glycerin 10%

[0029] Carbomer 940 1%

[0030] Triethanolamine 1.35%

[0031] Add distilled water or purified water or water for injection to 100%

[0032] The situation of utilizing the medicine of the present invention to carry out clinical trials is as follows:

[0033] treatment method

[0034] Grouping method Divide 100 patients into 4 groups according to the order of admission. Groups A and B are the treatment groups, including 25 cases of bacterial conjunctivitis (group A) and 25 cases of bacterial keratitis (group B), treated with gatifloxacin gel eye drops, 1-2 drops each time , 2 times a day. Groups C and D are the control group, including 25 cases of bacterial conjunctivitis (group C) and 25 cases of bacterial keratitis (group D), treated with 0.3% ciprofloxacin eye drops, 1-2 drops each time ...

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PUM

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Abstract

An ocular Jiatishaxing gel contains Jiatishaxing, carbomer and triethanol amine. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an externally used medicine for treating eye infections and a preparation method thereof, in particular to a slow-release eye gel for treating eye infections and a preparation method thereof. Background technique [0002] So far, there are few varieties of antibiotics for the treatment of eye infectious diseases, and the products are aging. The current clinical preferred antibiotics are compound preparations of ciprofloxacin hydrochloride, tobramycin and dexamethasone (trade name: Tobrex). The disadvantage of Tobrex is that the price is relatively expensive. In contrast, the price of ciprofloxacin hydrochloride eye drops is relatively low. However, ciprofloxacin hydrochloride eye drops are more irritating to the eyes and are difficult for patients to accept. Especially the long-term use of old antibiotic eye drops causes the increasing number of antibiotic-resistant bacteria, so the therapeutic effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/496A61P27/02
Inventor 李东
Owner 深圳市华晖生物科技有限公司
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