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Arbidol containing compound preparation

A compound preparation, the technology of Arbidol hydrochloride, which is applied in the field of antiviral drug Arbidol hydrochloride compound preparation, can solve the problems of uncertain curative effect, accompanied by nasal congestion, sneezing, sore throat, side effects of amantadine, etc.

Inactive Publication Date: 2011-11-02
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] It can be seen from Table 1 that fever, headache, general pain, fatigue, weakness, chest discomfort, and cough are common symptoms of influenza, and sometimes accompanied by nasal congestion, sneezing, and sore throat. Most of the compound cold medicines currently used clinically are For the above-mentioned symptoms of common cold or flu, there are few compound cold medicines that have antiviral effect and can fundamentally treat flu. Most of the antiviral ingredients are amantadine, which only has a certain effect on influenza A. Its curative effect is uncertain, and amantadine also has certain side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Embodiment one: Arbidol hydrochloride / ibuprofen granules (1g / bag)

[0065] (1) Formulation:

[0066] Particle I:

[0067]

[0068] Particle II:

[0069]

[0070] (2) Operation steps:

[0071] ① Preparation of adhesive: Dissolve yellow 6# in a small amount of water and mix with 2% hydroxypropyl methylcellulose 60% ethanol solution;

[0072] ②Granulation I: Mix Arbidol hydrochloride crushed through a 100-mesh sieve with mannitol and sucralose in a mixing granulator, add an appropriate amount of binder to granulate, and dry at 50-55°C;

[0073] ③Granulation II: Mix ibuprofen and mannitol through a 100-mesh sieve evenly in a mixing granulator, add an appropriate amount of binder to granulate, and dry at 50-55°C.

[0074] ④ Mix granule I with granule II, add sweet orange powder essence according to the weight of dry granules, mix evenly, and pack them in aluminum foil bags.

Embodiment 2

[0075] Embodiment two: Arbidol hydrochloride / ibuprofen tablet (485mg / tablet)

[0076] (1) Formulation:

[0077] Particle I:

[0078]

[0079] Particle II:

[0080]

[0081] (2) Operation steps:

[0082] ①Granulation I: Mix Arbidol hydrochloride crushed through a 100-mesh sieve with starch, microcrystalline cellulose, and cross-linked polyvinylpyrrolidone in a mixing granulator, and add an appropriate amount of 10% povidone 50% ethanol solution Granulate, dry at 50-55°C;

[0083] ②Granulation II: Mix ibuprofen, starch and microcrystalline cellulose passed through a 100-mesh sieve evenly in a mixing granulator, add an appropriate amount of 10% povidone 50% ethanol solution to granulate, and dry at 50-55°C.

[0084] ③ Mix granule I with granule II, add magnesium stearate according to the dry granule weight, mix evenly, and press into tablets.

[0085] ④ Put the tablet core in the coating pan and coat the stomach-soluble film coat

Embodiment 3

[0086] Embodiment three: Arbidol hydrochloride / ibuprofen / pseudoephedrine hydrochloride tablet (500mg / sheet)

[0087] (1) Formulation:

[0088] Particle I:

[0089]

[0090] Particle II:

[0091]

[0092]

[0093] (2) Operation steps:

[0094] ①Granulation I: Mix Arbidol hydrochloride crushed through a 100-mesh sieve with starch, microcrystalline cellulose, and cross-linked polyvinylpyrrolidone in a mixing granulator, and add an appropriate amount of 10% povidone 50% ethanol solution Granulate, dry at 50-55°C;

[0095] ②Granulation II: mix pseudoephedrine hydrochloride and starch passing through a 100-mesh sieve in equal amounts, then mix evenly with ibuprofen and microcrystalline cellulose passing through a 100-mesh sieve in a mixing granulator, and add an appropriate amount of 10 % povidone 50% ethanol solution to granulate and dry at 50-55°C.

[0096] ③ Mix granule I with granule II, add magnesium stearate according to the dry granule weight, mix evenly, and p...

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PUM

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Abstract

The present invention relates to a compound preparation containing antiviral drug arbidol, which is especially adapted to respiratory tract infection disease caused by virus. During the respiratory tract infection period, the patient has the discomfort symptoms of fever and nose stuff, therefore, the anti influenza compound preparation on the invention also includes one, two or three of the ibuprofen, alcaine pseudoephedrine, and dextromethorphan hydrobromide on the basis of including alcaine arbidol, and is then added with take orally preparation medicinal adjuvant to make take orally solid dosage forms. The medical effect experiment shows that the cooperation of the active components in the compound preparation is well, and the preparation is convenient in used by patient.

Description

technical field [0001] The invention relates to a compound preparation of antiviral drug Arbidol hydrochloride, in particular to a compound preparation for treating influenza and various symptoms thereof. Background technique [0002] Influenza (influenza, referred to as influenza) is an acute respiratory infectious disease caused by influenza virus, and is one of the major public health problems faced by human beings. According to statistics, the annual incidence rate of influenza is 10% to 30%, and its epidemiological most notable features are: sudden outbreak, rapid spread, and widespread spread. Influenza epidemics have certain seasonality. It often occurs in winter in northern my country, while it occurs in winter and summer in the south. The incidence rate of influenza is high, and the population is generally susceptible. my country is a high-incidence area of ​​influenza, and three of the four worldwide pandemics in the 20th century originated in my country. There...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/439A61P31/16A61K31/192A61K31/137A61K31/405
Inventor 刘振涛牛占旗刘立云申东民王莉芳陈玉洁王荣端冯小龙
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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