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Method for determining contents of miconazole nitrate and triamcinolone acetonide in Qumicin cream

A technology of triamcinolone acetonide acetate and miconazole nitrate, which is applied in the field of quality control of trimide cream, and can solve problems such as low specificity, long color development time, and unstable results

Inactive Publication Date: 2005-05-11
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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Problems solved by technology

However, the preparation of the test solution by this method is cumbersome, the color development time is long, the specificity is not strong, and the result is unstable due to the influence of various factors.
[0003] The literature also has a small amount of research on the quality control method of Trimixin cream, but it all selects different internal standards, and adopts the high-performance liquid phase internal standard method to measure the content of triamcinolone acetonide acetate or miconazole nitrate, but these methods There are still problems such as cumbersome operation process, complex calculation formula, purchase of internal standard reference substance, and increased cost of quality control

Method used

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  • Method for determining contents of miconazole nitrate and triamcinolone acetonide in Qumicin cream
  • Method for determining contents of miconazole nitrate and triamcinolone acetonide in Qumicin cream
  • Method for determining contents of miconazole nitrate and triamcinolone acetonide in Qumicin cream

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Embodiment Construction

[0062] 1. Test conditions:

[0063] Triamcinolone acetonide acetate reference substance: batch number 100125-0103; miconazole nitrate reference substance: batch number 10213-9903; methanol is chromatographically pure, water is redistilled water, and other reagents are analytically pure; Agilent1100 series quaternary pump; detector : Agilent1100 series DAD; Agilent HPCHEM workstation.

[0064] 2. Chromatographic conditions:

[0065] Chromatographic column: Waters Symmetry C18 column 5μm (3.9×150mm); mobile phase: methanol-0.2mol / L sodium dihydrogen phosphate solution (72:28); flow rate: 1.0ml / min; detection wavelength: 240nm; column temperature: room temperature ; Injection volume: 5 μl; Autosampler.

[0066] 3. Content determination:

[0067] Take triamcinolone acetonide reference substance and miconazole nitrate reference substance, accurately weighed, add methanol to dissolve and quantitatively dilute to make about 0.025mg triamcinolone acetonide reference substance and 0...

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Abstract

A method for determining content of triamcinolone acetonide acetate and micronazole nitrate in qumixing emulsifiable paste utilizes high efficiency liquid plase external standard method to determine simultaneously out content of triamcinolone acetonide acetate and miconazole nitrate in qumixing emulsifiable paste.

Description

technical field [0001] The invention relates to a method for controlling the quality of Qumixin cream, in particular to a method for determining the content of Triamcinolone acetate and miconazole nitrate, the main components of the Trimethin cream. Background technique [0002] Qumixin Cream (formerly known as Pikang Cream) is a compound ointment preparation, the main component of which is triamcinolone acetonide acetate (C 26 h 33 FO 7 ), miconazole nitrate (C 18 h 14 Cl 4 N 2 O HNO 3 ), neomycin sulfate, matrix, etc. The current quality standard is "National Drug Standard" WS-10001-(HD-0155)-2002, and the content of the single component of triamcinolone acetonide acetate is determined by colorimetry. However, the preparation of the test solution by this method is cumbersome, the color development time is long, the specificity is not strong, and the result is unstable due to the influence of various factors. [0003] The literature also has a small amount of resea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N30/02G01N30/06G01N30/60
Inventor 李楚源庞志清宋丽军陈矛杨东升王德勤陈薇
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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