45 results about "Triamcinolone diacetate" patented technology

A method for determining content of triamcinolone acetonide acetate and micronazole nitrate in qumixing emulsifiable paste utilizes high efficiency liquid plase external standard method to determine simultaneously out content of triamcinolone acetonide acetate and miconazole nitrate in qumixing emulsifiable paste.

The invention discloses a process for synthesizing triamcinolone acetonide acetate. The process comprises the steps of firstly, taking an acetic acid tetraene material as a raw material, and obtaining an oxide through an oxidation reaction under the effect of methanoic acid and potassium permanganate; secondly, taking the oxide as a raw material, and obtaining a ring-reducing material through a ring-reducing reaction under the effect of perchloric acid and N-bromosuccinimide; thirdly, taking the ring-reducing material as a raw material, and conducting a fluorination reaction under the effect of fluorine hydride and dimethylformamide to obtain a triamcinolone acetonide acetate crude product; and fourthly, purifying the triamcinolone acetonide acetate crude product to obtain the triamcinolone acetonide acetate. The process is mild in reaction condition, easy to control, low in toxicity and dangerousness of used auxiliary materials, low in pollution and applicable to industrial production, the triamcinolone acetonide acetate which is synthesized by the process is subjected to high performance liquid chromatography (HPLC) detection, the purity can exceed 99%, and the yield is high.

The invention provides a medical product containing solution-type triamcinolone acetonide acetate. The medical product contains triamcinolone acetonide acetate, sulfobutyl ether-beta-cyclodextrin and sodium hyaluronate. The medical product containing solution-type triamcinolone acetonide acetate is small in local irritation in clinic use, especially when the medical product is applied to intra-articular injection, the product is easy to absorb, the particle deposition on the surface of the periosteum existing in the suspension type triamcinolone acetonide acetate medical product is avoided, and the periosteum injury caused by particle deposition is reduced.

The invention discloses a terbinafine compound preparation for treating eczema, dermatitis, body ringworm, tinea cruris, tinea manus and pedis and the preparation method; the invention mainly uses terbinafine hydrochloride and clobetasol propionate or triamcinolone acetonide acetate, which is further matched with O/W emulsion matrix for the preparation of cream. The invention is characterized by fast onset of action, short treatment course and low recurrence rate for treating skin fungal infection with local inflammatory or chronic eczema.

A medical composition includes Bifonazole and Triamcinolone acetonide acetate, and is mixed with pharmaceutical acceptable accessory. The medical composition of the present invention is used in treatment of skin superficial fungal infections, and also has the dual role of anti-inflammatory, anti-allergy and anti-itching functions.

The invention discloses a triamcinolone acetonide acetate particle, and a preparation method and a medicinal composition thereof. The preparation method comprises the following steps: 1) heating and dissolving triamcinolone acetonide acetate with aqueous solution of ethanol, naturally cooling the obtained solution to obtain acicular crystals, washing away the ethanol from the crystals with water for injection, drying the washed crystals, and then adding the crystals into water for injection at a temperature of 0 to 10 DEG C; 2) linearly adding dropwise triamcinolone acetonide acetate solution dissolved with dimethyl formamide solution into the mixed solution of the water for injection at the temperature of 0 to 10 DEG C obtained in the step 1), simultaneously stirring the mixed solution, keeping the temperature of the mixed solution at 0 to 15 DEG C, and continuing stirring the mixed solution for 1 to 30 minutes to obtain a mixture of water and crystals; and 3) as usual, filtering the mixture of the water and the crystals obtained in the step 2) and vacuum-drying the obtained crystals. The invention adopts a crystal inoculation process, thus crystals of the prepared triamcinolone acetonide acetate particles have regular shapes and uniform particle sizes; crystallization is free from jet milling and the physicochemical property of the particle is stable; and no crystal expansion phenomenon generates in the prepared triamcinolone acetonide acetate suspension injection during storage.

The invention provides a full-novel synthesizing route for preparing triamcinolone acetonide acetate. According to the full-novel synthetic route, utilized raw materials have lower cost and more easiness in obtaining. The synthetic route comprises the steps of hydroxylating reaction raw materials and protecting, then selectively oxidizing five-membered ring double bonds, removing a protecting group, then protecting oxidized di-hydroxyl, then epoxidizing six-membered ring double bonds, performing open-ring fluorination and esterfying hydroxyl to obtain a triamcinolone acetonide product. A reaction process has easiness in operation, yields of all the steps are higher, obtained products have higher purities, byproduct generation is effectively avoided, production cost is reduced, and industrial production is facilitated.

The present invention relates to an ointment for external application for curing dermatosises of psoriasis, neurodermatitis, allergic dermatitis, cutaneous pruritus, beriberi, mosquito bite and infantile eczema, etc. with obvious therapeutic effect. Said ointment is made up by using (by wt%) 30-60% of tramcinolone acetonide acetate urea cream, 15-30% of compound sulfamethoxazole, 10-20% of prednisone acetate and 10-20% of chlorpheniramine maleate. Besides, said invention also provides its production method and concrete steps.

A medicine for treating psoriasis is prepared from realgar, natural indigo, red sage root, traimcinolone acetonide hydrochloride, VE, VBb, VC and urea.

The invention discloses a compound zinc undecylenate triamcinolone acetonide ointment and a preparation method thereof. The invention relates to the field of medicine. The compound zinc undecylenate triamcinolone acetonide ointment provided by the invention is composed of zinc undecylenate, undecylenic acid, triamcinolone acetonide acetate, and an emulsion substrate. Compared to existing technologies, the preparation method is advantaged in controllable temperature and simple formula, and the product is advantaged in good characters. With the added triamcinolone acetonide acetate, comprehensive inflammation resisting and allergy resisting effects of the medicine are stronger and more durable. The product and the method are especially suitable for industrial productions.

The present invention discloses a medicine composition for curing dermopathy and its preparation method. Said medicine composition contains the following components: (by weight portion) 0.3-3.0 portions of naftifine and 0.005-0.50 portion of one component selected from halcinonide, triamcinolone acetonide acetate, betamethasone (containing betamethasone propionate and betamethasone valerate) or clobetasol propionate. Said medicine composition can be made into various medicine preparations for external application.

The invention provides a preparation method for a solution type triamcinolone acetonide acetate injection. The preparation method comprises the following concrete steps: in the presence of an organic solvent, stirring triamcinolone acetonide acetate and sulfobutyl ether-beta-cyclodextrin until the obtained mixture is clear; then removing the organic solvent through evaporation; and adding an aqueous sodium hyaluronate solution, dilution water, etc. The preparation method for the solution type triamcinolone acetonide acetate injection is simple; the prepared injection has small local irritation in clinical application; and triamcinolone acetonide acetate can be easily absorbed especially when the injection is applied to intra-articular injection, and the problem of deposition of particles on the surface of periosteum caused by a suspension type triamcinolone acetonide acetate injection is avoided, so damage of the particles to the periosteum can be reduced.

The invention belongs to the field of pharmaceutical preparations and in particular relates to chitosan modified triamcinolone acetonide acetate lipidosome eye drops and a preparation method thereof.The invention provides chitosan modified triamcinolone acetonide acetate lipidosome prepared prepared by a calcium acetate gradient method. The preparation method comprises the following steps: preparing a lipid membrane from soya bean lecithin and cholesterol, adding a calcium acetate solution to prepare blank liposome, adding triamcinolone acetonide acetate to obtain triamcinolone acetonide acetate lipidosome, and performing chitosan coating, thereby obtaining the chitosan modified triamcinolone acetonide acetate lipidosome. The lipidosome has excellent pharmaceutical property, the liposomesurface presents positive charge, and the lipidosome and a sodium hyaluronate solution are prepared into the eye drops, so that the water solubility of the triamcinolone acetonide acetate and the adsorptivity to cornea can be improved, and the drug toxicity can be reduced. Compared with injection, the chitosan modified triamcinolone acetonide acetate lipidosome eye drops are simple and safe to use.

The invention relates to a method for improving the stability of a triamcinolone acetonide preparation. The triamcinolone acetonide preparation is prepared from the following components: 100-150g of triamcinolone acetonide acetate, 0.2-0.5g of 15-hydroxyl stearic acid polyethylene glycol ester, 30-50g of sodium carboxymethyl cellulose, 2-5g of salicylic acid, 70-100L of 2-propylene glycol, 40-60L of 5% ethanol and the balance of water for injection; the pH value of the triamcinolone acetonide preparation is 4-7. Sodium chloride is added into a triamcinolone acetonide acetate solution, and the amount of the sodium chloride is selected to be limited, so that the problem that the content of the triamcinolone acetonide acetate is reduced in a standing process of a compound triamcinolone acetonide solution is solved; furthermore, the sodium chloride is cheap and less in consumption, so that the method is lower in production cost and suitable for industrial production and application; in addition, the sodium chloride does not affect the cleanliness of the active ingredients in the solution, and does not affect the safety and effectiveness of the solution.

The invention relates to a compound triamcinolone acetonide salicylic acid liniment. Each 100ml of the liniment is prepared from the following components: 0.01 to 0.2 g of triamcinolone acetonide acetate, 1 to 5g of chloramphenicol, 1 to 5g of salicylic acid, 1 to 5ml of azone, 1 to 5ml of dimethyl sulfoxide, 5 to 20ml of propylene glycol and the balance of 95 percent ethanol aqueous solution. The compound triamcinolone acetonide salicylic acid liniment disclosed by the invention is remarkable in psoriasis treatment effect, stable and reliable in quality, simple in preparation process and capable of realizing industrial production.

The invention discloses a triamcinolone acetonide acetate injection and a preparation method thereof. The injection is prepared from 10.0g of triamcinolone acetonide acetate, sodium chloride which is 5.00-20 percent of the injection in a weight-to-volume ratio, sodium merthiolate which is 0.005-0.01 percent of the injection in a volume ratio, HS-15 which is 1.00-15 percent of the injection in a volume ratio, sodium carboxymethylcellulose which is 10.00-30 percent of the injection in a volume ratio and the balance of water for injecting. The preparation method comprises the following steps: putting triamcinolone acetonide acetate, sodium merthiolate, sodium chloride and sodium carboxymethylcellulose in a beaker according to the prescription, adding partial water for injecting, uniformly stirring, adding activated carbon, uniformly stirring, and filtering to obtain a solution (1); weighing a proper amount of water for injecting at 30-40 DEG C, adding HS-15 which is 1.00-15 percent of the injection in a volume ratio, and uniformly stirring to obtain a solution (2); mixing the solution (1) and the solution (2), uniformly stirring, adding the water for injecting to total amount, regulating the pH value of the mixture to be 5.5-7.0 by using acetic acid, filtering and filling and sealing. By adopting a brand-new prescription and process, a produced product has stable quality, and the safety of clinical administration can be remarkably improved.

The present invention provides a sustained drug delivery system for the treatment of age-related macular degeneration (AMD), comprising corticosteroid encapsulated nanoparticles incorporated into a thermoreversible hydrogel. The corticosteroid may be triamcinolone acetate (TA), dexamethasone, or loteprednol etabonate (LE). The proposed drug delivery system is nontoxic to ARPE-19 (retinal pigment epithelium) cells and significantly reduces VEGF (vascular endothelial growth factor) expression as compared to solutions of the coticosteroids. The present invention provides sustained delivery of the corticosteroid to the posterior segment of the eye, reducing the frequency of intraocular injections necessary to maintain therapeutic concentrations.

The invention discloses a compound preparation for treatment of psoriasis; the compound preparation includes econazole nitrate, triamcinolone acetonide acetate, ketoconazole and a plurality of accessories. With use of the formula of the compound preparation for preparing a drug, the charges for medicines can be reduced, the curative effect is improved, and effective treatment of psoriasis is achieved.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of fluocinonide. According to the preparation method, triamcinolone acetonide acetate is taken as a raw material, N-fluorobenzenesulfonamide and a free radical initiator are added into the triamcinolone acetonide acetate for reaction, and fluocinonide acetate is obtained. According to the method, the problems of complicated operation, more byproducts, dangerous reagents and great environmental harm in the process of easily adding fluorine into fluorine acetate are solved, the yield is increased, and large-scale production is easier.

The invention discloses an eyedrop recipe which comprises the following raw materials in parts by weight: 0.5 to 0.9 part of chloramphenicol, 0.2 to 0.3 part of naphazoline hydrochloride, 0.3 to 0.8 part of triamcinolone acetonide acetate and 7000 to 8000 parts of Hertz functional water. The recipe is prepared from the following raw materials in parts by weight: 0.8 part of chloramphenicol, 0.25 part of naphazoline hydrochloride, 0.5 part of triamcinolone acetonide acetate and 7500 parts of Hertz functional water. A preparation method of an eyedrop using the recipe comprises the following steps of firstly mixing the chloramphenicol and the naphazoline hydrochloride according to the recipe quantities; adding the Hertz functional water; performing uniform stirring; then, adding the triamcinolone acetonide acetate; performing sufficient and uniform mixing; charging the materials into a high-temperature sterilized bottle; and performing sealing for use. The eyedrop using the recipe provided by the invention can be used for various kinds of eye discomfort, and has the special effects on vitreous opacity, slight cataract, keratitis, pinkeye, welding wounded eye diseases, dry or itching eye syndromes and the like.