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Compound triamcinolone acetonide film coating agent and preparation method thereof

A technology of triamcinolone acetonide acetate and film-coating agent, which is applied in the direction of pharmaceutical formulations, local antibacterial agents, medical preparations containing active ingredients, etc., can solve problems such as the preparation of triamcinolone acetonide acetate film-film preparation that has not been seen, and achieve the goal of promoting The effect of growth and development, convenient use, and simple preparation process

Inactive Publication Date: 2015-11-11
CHENGDU YICHUANGSI BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Triamcinolone acetonide acetate is an adrenal cortex hormone drug with strong anti-inflammatory and anti-allergic effects and is relatively long-lasting. External skin preparations are suitable for various skin diseases, such as neurodermatitis, eczema, psoriasis, etc. Liquid, tablet, capsule, existing gel, eye drop, ear drop and suppository etc., but have not seen the preparation of relevant triamcinolone acetonide acetate coating

Method used

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Embodiment

[0022] The compound triamcinolone acetonide coating agent of the present embodiment is expressed in parts by weight, specifically comprising 0.05 g of triamcinolone acetonide acetate, 0.5 g of zinc glutamate, 4.0 g of chitosan, 1.0 mL of dimethyl sulfoxide, lauryl nitrogen? Ketone 1.0g, propylene glycol 10g, purified water 30mL, enough ethanol solution.

[0023] Wherein, the chitosan is a chitosan with a viscosity of 50 mPa·s and a stripping limit of not less than 80%; the ethanol solution is an ethanol solution with an ethanol concentration of 75%.

[0024] Concrete preparation method comprises the following steps:

[0025] (1) Take 4.0g of chitosan, sprinkle it evenly into 30mL of purified water, let it swell naturally, then add 0.5g of zinc glutamate, stir to dissolve, and obtain a mixed solution for use;

[0026] (2) Dissolve 0.05g of triamcinolone acetonide acetate in 1mL of dimethyl sulfoxide and 10g of propylene glycol, then add 1.0g of laurocapram, and stir well;

[...

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Abstract

The invention discloses a compound triamcinolone acetonide film coating agent and a preparation method thereof. The compound triamcinolone acetonide film coating agent is suitable for various skin diseases such as neurodermatitis, eczema and psoriasis. Triamcinolone acetonide acetate has effects of diminishing inflammation and resisting allergy. Zinc glutamine has effects of convergence and antibiosis and can participate in synthesis of a plurality of enzymes in the body, improve immunity and promote growth and development. The film coating agent prepared from triamcinolone acetonide acetate and zinc glutamine as main raw materials has effects of resisting gram positive cocci and gram negative bacilli. The compound triamcinolone acetonide film coating agent prepared from chitosan has no oily feel, can be spread easily, has strong adhesion and a certain tearing strength, is convenient for use, and has no irritation on skin. The preparation method has simple processes, realizes stable quality, utilizes high performance liquid chromatography to determine triamcinolone acetonide content, prevents accessory material-caused interference on determination, has simple processes, can produce a reliable result and is suitable for preparation quality control.

Description

technical field [0001] The invention relates to the technical field of coating agent preparation, in particular to a compound triamcinolone acetonide coating agent and a preparation method thereof. Background technique [0002] Triamcinolone acetonide acetate is an adrenal cortex hormone drug with strong anti-inflammatory and anti-allergic effects and is relatively long-lasting. External skin preparations are suitable for various skin diseases, such as neurodermatitis, eczema, psoriasis, etc. Liquid, tablet, capsule, existing gel, eye drop, ear drop and suppository etc., but do not see the preparation of relevant triamcinolone acetonide acetate coating agent yet. Contents of the invention [0003] The object of the present invention is to provide a compound triamcinolone acetonide coating agent for external skin with strong and durable anti-inflammatory and anti-allergic effects. [0004] Another object of the present invention is to provide a preparation method of compou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/58A61K31/198A61P31/02
Inventor 周洁
Owner CHENGDU YICHUANGSI BIOLOGICAL SCI & TECH
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