5 results about "Intraocular Injections" patented technology

Provided is an intraocular injection assembly, comprising an injection needle base and an injection needle head. The injection needle base is internally provided with a plurality of first auxiliary channels, each extending in an axial direction of the injection needle base, which are in sequential communication with each other, and in a direction from a first end to a second end of the injection needle base, the diameters of the plurality of first auxiliary channels sequentially decrease, and the plurality of first auxiliary channels cooperate to form a first injection channel. The injection needle head is internally provided with at least two second auxiliary channels, each extending in an axial direction of the injection needle head, which are in sequential communication with each other, and in a direction from a first end to a second end of the injection needle head, the diameters of the second auxiliary channels sequentially decrease, and the second auxiliary channels cooperate to form a second injection channel. The injection needle head is connected to the second end of the injection needle base, and the first end of the injection needle base can be connected to an outlet of an external syringe, such that the second injection channel is in communication with the external syringe by means of the first injection channel.

This utility model relates to the field of restraint technology for laboratory monkeys, specifically to a supine restraint device for eye experiments on laboratory monkeys. The device includes: a support plate with a groove, and a rotating seat extending along the groove; a head support component connected to the rotating seat and tiltable at a predetermined angle relative to the rotating seat; and a back support component connected to the groove and movable relative to the support plate along the length of the groove to a predetermined position. This restraint device supports the laboratory monkey in a supine position through three support points: head, back, and buttocks. This ensures the monkey is in a neutral position, preventing lateral tilting and facilitating intraocular injection, while minimizing restraint. This allows for observation of conditioned reflexes in monkeys under deep anesthesia and prevents accidental death.

Methods of treating ocular diseases such as age-related macular degeneration may include the administration of peptides comprising complement factor H and factor H-like protein domains to reduce an amount of geographic atrophy in a subject in need thereof. These methods may be administered by intraocular, intervascular or subcutaneous injection.

This invention provides the use of spermidine or a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating autoimmune uveitis. The medicament is formulated as an oral or intraocular injection. The medicament is used to rebuild ocular immune tolerance by promoting autophagy flux activation and downregulating the expression of LCN2 protein in local tissues, inhibiting the differentiation of CD4+ T cells into Th17 cells and promoting their differentiation into Treg cells. Spermine exhibits significant efficacy and high safety in treating autoimmune uveitis.

This invention discloses a fixation table for zebrafish microsurgery, belonging to the field of biological experimental instrument technology. The fixation table includes a culture device, a silicone fish sleeve, a compression ring, a universal ball joint mechanism, and a connector. The silicone fish sleeve is a hollow, flexible, contoured sleeve with a compression ring at its expanded end. By rotating the compression ring, the flexible wall of the silicone fish sleeve contracts inwards uniformly, wrapping and fixing the zebrafish's body in a non-invasive manner. The locking end of the fish sleeve exposes the fish's head, facilitating surgical operations. The universal ball joint mechanism connects to the compression ring via the connector, enabling rapid adjustment and locking of the fish body at any angle in three-dimensional space, meeting the needs of various surgical positions such as upright, inverted, and lateral placement. This invention solves the problems of easy slippage, uneven pressure, difficulty in body position adjustment, and cumbersome operation in existing zebrafish fixation methods, and is suitable for various delicate microsurgeries such as mandibular bone injuries, intraocular injections, and craniotomy.