Intraocular injection for treating infectious endophthalmitis

An endophthalmitis and injection technology, applied in the field of medicine, can solve the problems of many complications and inadequate control of drug dosage, and achieve good therapeutic effect.

Inactive Publication Date: 2009-06-17
戴成华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, due to this method, the dosage of the drug is not in place, and there are many complications, so it is not accepted by the majority of ophthalmology departments and patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Take 15 mg of norvancomycin hydrochloride with a concentration of 1.5% and 5 mg of dexamethasone sodium phosphate with a concentration of 0.5% and mix them in patients with infectious endophthalmitis (pain accompanied by loss of vision for one week). , edema, conjunctival mixed hyperemia, corneal edema, vitreous pus, A / B ultrasonography showed vitreous flocculent opacity in the left eye, diagnosed as left eye infectious endophthalmitis. Puncture the needle through the pars plana of the ciliary body of the left eye, extract 0.3ml of vitreous body, slowly inject 00.3ml of compound vancomycin injection into the vitreous cavity of the eye through the same needle, and inject another injection of compound vancomycin into the vitreous cavity three days later After a week, he recovered from illness. The vision of the right eye was 0.6, and that of the left eye was 0.4. The extracted vitreous body was cultured and tested for drug sensitivity. It was Staphylococcus epidermidis inf...

Embodiment 2

[0012] With the above-mentioned medicine of the same formula and the same mass ratio, the patient suffering from infectious endophthalmitis after left eye cataract is treated. Get 0.2ml of Norvancomycin Hydrochloride Injection, 3mg of 1.5% Norvancomycin Hydrochloride, 1mg of 0.5% Dexamethasone Sodium Phosphate, and recover from injury after 2 injections into the left eye of the patient undergoing the operation.

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PUM

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Abstract

The invention relates to an intraocular injection for treating infectious endophthalmitis, which is a drug for treating the infectious endophthalmitis. According to clinical studies and animal experiments, because of the incorrect selection of drugs, drug concentration and safe and effective doses, the toxicity causes damages to retina. 1.5 percent norvancomycin hHydrochloride and 0.5 percent dexamethasone sodium phosphate are mixed together according to the mass ratio of 3:1, thereby obtaining specific effects on the treatment of endophthalmitis patients. The intraocular injection has the advantages of significant curative effect, no toxicity, no side effects, and the like.

Description

technical field [0001] The invention relates to an ophthalmic vitreous cavity injection, which is suitable for the treatment of intraocular infections of human eyeballs and belongs to the technical field of medicine. Background technique [0002] Infectious endophthalmitis, whether it is exogenous: caused by trauma or surgery, or endogenous, caused by blood transfer, is the most terrible, serious and destructive disease in ophthalmology, and the prognosis is extremely poor. In severe cases, the eyeball must often be removed, and sometimes blood transfer can cause sepsis, which is life-threatening. In 1944, Vonsallman first used penicillin as an intraocular injection to treat endophthalmitis, and later some authors confirmed his therapeutic effect. Unfortunately, due to this method, the drug dosage is not in place, and there are many complications, so it is not accepted by the majority of ophthalmology departments and patients. Since 1970, ophthalmologists have conducted a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/14A61K31/661A61P31/04A61P27/02
Inventor 戴成华
Owner 戴成华
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