Triamcinolone acetonaide acetate nano eye drops and preparation method thereof

A technology of triamcinolone acetonide acetate and eye drops, applied in the field of medicine, can solve the problems of short-term efficacy, poor effect, low bioavailability and the like, and achieve the effect of easy use

Inactive Publication Date: 2012-01-25
严宏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical application, long-term systemic use of glucocorticoids will produce some toxic and side effects. When local application, due to fast drug metabolism, low bioavailability, short-term drug effect, multiple administrations, etc., the effect is often not good. good
In addition, multiple administrations in the eye will cause complications such as conjunctival edema and reduce the patient's tolerance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 10 mg of deoxycholic acid chitosan derivative and place it in a flask, add 3 ml of distilled water, stir to dissolve, weigh 5 mg of triamcinolone acetonide acetate, dissolve in 0.3 ml of tetrahydrofuran, and slowly (dropping speed less than 1 ml / min) dropwise add to the above shell Polysaccharide solution, then slowly add 1ml of distilled water dropwise, and keep stirring at room temperature for at least 24h. Then stir in a water bath not lower than 40°C to volatilize tetrahydrofuran. After the tetrahydrofuran was volatilized, the mixture was centrifuged (5000r / min, 5min), and the supernatant was the chitosan nanoparticles loaded with triamcinolone acetonide. Finally, the nanoparticles and distilled water were prepared as eye drops with a concentration of 1% and pH=7.5.

Embodiment 2

[0029] Weigh 8 mg of deoxycholic acid chitosan derivatives and place them in a flask, add 2.7 ml of distilled water, stir to dissolve, weigh 10 mg of triamcinolone acetonide acetate, dissolve in 0.675 ml of tetrahydrofuran, and slowly (drop speed less than 1 ml / min) dropwise to the above Chitosan solution, and then slowly drop distilled water 0.8ml, at room temperature and continue stirring for at least 24h. Then stir in a water bath not lower than 40°C to volatilize tetrahydrofuran. After the tetrahydrofuran was volatilized, the mixture was centrifuged (5000r / min, 5min), and the supernatant was the chitosan nanoparticles loaded with triamcinolone acetonide. Finally, the nanoparticles and distilled water are prepared into eye drops with a concentration of 1%-3% and pH=7.5.

Embodiment 3

[0031] Weigh 20mg of deoxycholic acid chitosan derivatives and place them in a flask, add 8ml of distilled water, stir to dissolve, weigh 10mg of triamcinolone acetonide acetate, dissolve in 0.8ml of tetrahydrofuran, and slowly (drop speed less than 1ml / min) dropwise into the above shell Polysaccharide solution, then slowly add 2ml of distilled water dropwise, and keep stirring at room temperature for at least 24h. Then stir in a water bath not lower than 40°C to volatilize tetrahydrofuran. After the tetrahydrofuran was volatilized, the mixture was centrifuged (5000r / min, 5min), and the supernatant was the chitosan nanoparticles loaded with triamcinolone acetonide. Finally, the nanoparticles and distilled water are prepared into eye drops with a concentration of 1%-3% and pH=7.5.

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PUM

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Abstract

The invention relates to triamcinolone acetonaide acetate nano eye drops and a preparation method thereof, wherein the triamcinolone acetonaide acetate nano eye drops are prepared in the way that the triamcinolone acetonaide acetate and the chitosan nano carrier are prepared into nanoparticles according to the proportion of 1 / 2 and then are mixed with the distilled water. The invention provides the triamcinolone acetonaide acetate nano eye drops which have simple preparation process, can prevent pain and complication which are caused by local injection, facilitate clinical use and are easy to be accepted by patients and the preparation method of the triamcinolone acetonaide acetate nano eye drops.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an eye drop and a preparation method thereof, in particular to a triamcinolone acetate nano eye drop and a preparation method thereof. Background technique [0002] Triamcinolone acetonide is a long-acting glucocorticoid, which has powerful anti-inflammatory effects, and has strong and long-lasting anti-inflammatory and allergic effects. It is also a commonly used drug in ophthalmology. It can not only relieve congestion, reduce the permeability of capillaries, inhibit the movement of inflammatory cells to the inflammatory site, but also prevent the reaction of inflammatory mediators such as kinins, histamine, and slow-reacting substances, inhibit the function of phagocytes, and stabilize lysate. Enzymosomal membrane, preventing complement from participating in inflammatory response, inhibiting the repair of tissue damage after inflammation, etc. In addition, it also has the effects of imm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/58A61K47/36A61P27/02A61P29/00A61P37/08
Inventor 严宏孙礼华
Owner 严宏
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