Yinhuang oral liquor and its producing process

Abstract

The present invention discloses a kind of Yinhuang oral liquid and its preparation process. The Yinhuang oral liquid consists of honeycuckle extract accounting in chlorogenic acid 6-24 mg/ml, skullcap root extract accounting in baicalin 12-48 mg/ml, stabilizer 18-72 mg/ml and pH regulator 0.1-1 mg/ml. The medicine has stable quality and high curative effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine oral liquid and a production process thereof, in particular to a Yinhuang oral liquid and a production process thereof. Background technique [0002] Yinhuang Oral Liquid is a dosage form modified by our factory on the basis of Yinhuang Tablets. Its main ingredients are honeysuckle extract and scutellaria baicalensis extract. It is used for acute tonsillitis, pharyngitis and other upper respiratory tract infections, and has good curative effect on the initial stage of cold and cough caused by cold, and also has the effect of preventing cold, hoarseness, cough, sore tongue, hepatitis, mumps and dysentery. The drug has been recorded in the "Pharmacopoeia of the People's Republic of China" on page 580 of the 2000 edition. Its production process is as follows: take the honeysuckle extract and the Scutellaria baicalensis extract and dissolve them in water respectively, and adjust the scutellaria baical...

AI Technical Summary

Problems solved by technology

But this product still has the following deficiencies: (1), during the storage process, with the prolongation of the storage time, the pH value of the liquid medicine gradually decreases, which can cause changes in the color and clarity of the liquid medicine and affect the quality of the medicine, especially the sterilization of the liquid medicine Afterwards, the PH value dropped more, sometimes by more than 1.0

(2) Scutellaria baicalensis extract contains baicalin, baicalein and other ingredients, among which baicalein has anti-inflammatory, anti-allergic, antibacterial, choleretic, diuretic, and anti-cholesterol effects, and is widely used in infectious hepatitis and nephritis , pyelonephritis and other diseases, but because baicalein is almost insoluble in water and does not contain carboxyl groups, it is insoluble in alkaline water, so it is difficult to dissolve and is filtered out as impurities, which affects the efficacy of medicines

At the same time, the solubility of baicalin in carboxyl-containing dilute alkali increases, but its stability is not good. At the same time, during storage, it can precipitate out of the solution with the change of the pH value of the solution, or hydrolyze to form baicalein, which is almost insoluble in water and produces precipitation, which affects the clarification of the drug. Spend

(3), chlorogenic acid is caffeic acid quinate, so it can be hydrolyzed by both acid and alkali, so the pH value of the drug solution is required to be high, and the pH of the drug solution is easily hydrolyzed after changing, which affects the efficacy of the drug. curative effect