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Technology for preparing capsule of liver cell growth promoting factor

A technology for preparing hepatocyte growth hormone and capsules is applied in the directions of capsule delivery, medical preparations containing active ingredients, and digestive systems, which can solve the problems of unfavorable large-scale production, high equipment requirements, and high production costs, and shorten the production cycle. , The effect of reducing production cost and convenient dosage control

Active Publication Date: 2005-06-22
浙江华缔药业集团有限责任公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

This preparation method has a high yield, and the biological activity of the polypeptide is basically not affected; but the equipment requirements are high, the production cost is high, and the output is low, which is not conducive to large-scale production

Method used

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  • Technology for preparing capsule of liver cell growth promoting factor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] see figure 1 , the preparation process of the hepatocyte growth-promoting hormone capsule comprises the following steps:

[0012] 1. Extract peptide dry powder.

[0013] The dry peptide powder is extracted from the hepatocyte growth-promoting hormone solution by alcohol precipitation method.

[0014] ①. First, pre-cool the hepatocyte growth-promoting hormone solution to below 10°C, and pre-cool the ethanol to below 10°C; add ethanol in an amount more than 1 times the volume of the solution to the hepatocyte growth-promoting hormone solution, and add six times in the example Add a certain amount of ethanol and stir while adding; then let it stand and refrigerate for 24 hours, and then separate the solid and liquid by centrifugation, and collect the precipitate, which is the dry polypeptide powder.

[0015] ②. Determine the polypeptide content of the mother liquor after collecting the precipitate. Repeat the operation ① for the mother liquor with a polypeptide content e...

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Abstract

The invention provides a technology for preparing capsule of liver cell growth promoting factor which comprises the steps of, extracting polypeptide dried powder from hepatocyte growth-promoting factors solution, charing diluent, mixing and palletizing, and loading into capsules, wherein the polypeptide dried powder extracting procedure comprises employing alcohol depositing method, charging ethanol into the solution of hepatocyte growth-promoting factors, refrigerating, separating, and collecting precipitation.

Description

technical field [0001] The invention relates to a preparation process of medical preparations, in particular to a preparation process of hepatocyte growth-stimulating hormone capsules. Background technique [0002] Hepatocyte growth-stimulating hormone has obvious effects in promoting DNA synthesis, mitosis, regulating cell growth and morphological formation; it has significant curative effect in treating some liver diseases such as hepatitis and cirrhosis. Freeze-dried powder injections and oral granules of hepatocyte growth-stimulating hormone are used as necessary adjuvant drugs in the comprehensive treatment of various liver diseases. The existing injection-type hepatocyte growth-stimulating hormone is expensive, needs intravenous injection, and is inconvenient to use; while the hepatocyte growth-stimulating hormone granule must be soaked in warm water and taken after brewing, the activity of the polypeptide is easily destroyed, which affects the therapeutic effect. Hep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K38/27A61P1/16A61P31/12
Inventor 高留根倪明敏周正兵
Owner 浙江华缔药业集团有限责任公司
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