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Synthesis method of insulin transporting system with insulin capturing function

A synthesis method and insulin technology, applied in the field of synthesis of insulin delivery system, can solve the problems of inability to form structural modifications, general limitations, and inability to systematically advance the common problems of insulin delivery system, and achieve stable properties and increased utilization. The effect of low rate and toxicity

Inactive Publication Date: 2019-12-03
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these substances can only play a role in a specific system, and their versatility in different systems is relatively limited. They have not been synthesized into a general component structure, so that a generalizable structural modification cannot be formed. It also cannot systematically promote the solution of the common problems of the insulin delivery system

Method used

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  • Synthesis method of insulin transporting system with insulin capturing function
  • Synthesis method of insulin transporting system with insulin capturing function
  • Synthesis method of insulin transporting system with insulin capturing function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Such as figure 1 with figure 2 Shown, a kind of synthetic method of the insulin delivery system with insulin trapping function of the present invention, described synthetic method comprises the following steps: (1) select monoamino β-cyclodextrin, its molecular formula is:

[0024]

[0025] (2) Use monoamino β-cyclodextrin as a medium for locating and capturing insulin, and fully stir and mix with insulin in aqueous solution to combine to form insulin molecules with capture labels; since monoamino β-cyclodextrin has internal hydrophobicity , the external hydrophilic nature, and there are many hydrophobic groups on the surface of insulin. In aqueous solution, monoamino β-cyclodextrin will actively combine with the hydrophobic groups on the surface of insulin.

[0026] (3) Using genipin as the cross-linking agent and chitosan as the backbone, under the condition of pH=3.8, stir in an environment of 8°C for 18 hours to complete the cross-linking of amino groups, and c...

Embodiment 2

[0030] In step (3), under the condition of pH = 4.5, stir at 15°C for 30 hours; and the cross-linking agent genipin and chitosan are first stirred in an aqueous solution to form a polymer at room temperature, and the stirring time is 6 hours. Same as Example 1.

Embodiment 3

[0032] In step (3), under the condition of pH=4, stir at 10°C for 24 hours; and the cross-linking agent genipin and chitosan are first stirred in an aqueous solution to form a polymer at room temperature, and the stirring time is 4 hours. Same as Example 1.

[0033]Examples 1 to 3, this application intends to propose new solutions to existing relatively basic and specific problems in insulin transport research on the basis of previous studies. Taking the interaction between β-cyclodextrin and the hydrophobic structure of insulin as a starting point, a transport system with insulin trapping function was constructed, which provided new ideas for the innovative application of classic materials in insulin transport systems. At the same time, through the development of components with a certain degree of versatility, it is possible to systematically optimize the efficiency of the transportation system and promote the solution of common problems in different transportation systems a...

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Abstract

The invention particularly relates to a synthesis method of an insulin transporting system with an insulin capturing function, and belongs to the technical field of medical drug synthesis. The synthesis method comprises the following steps: (1) monoamino beta cyclodextrin is selected; (2) the monoamino beta cyclodextrin is taken as a medium for positioning and capturing insulin and fully stirred and evenly mixed with the insulin in an aqueous solution, so that the monoamino beta cyclodextrin and the insulin are combined, and an insulin molecule with a capturing marker is formed; and (3) genipin is adopted as a crosslinking agent, chitosan is adopted as a backbone, crosslinking of amino is completed, the chitosan is crosslinked with the monoamino beta cyclodextrin to capture the insulin, and thus nano particles with the captured the insulin are formed. The synthesis method is common in reaction, high in feasibility and mild in condition, and the bioactivity of the insulin is not destroyed; a material adopted in the synthesis method is extremely low in toxicity, the genipin is the natural crosslinking agent, and compared with other common crosslinking agents, the toxicity of the genipin is extremely low; and the cyclodextrin and the chitosan are also common natural substances and hardly have biotoxicity.

Description

【Technical field】 [0001] The invention relates to the technical field of synthetic medical drugs, in particular to a method for synthesizing an insulin transport system with the function of trapping insulin. 【Background technique】 [0002] The accumulation in recent years has made researchers gradually realize that diabetes is a comprehensive endocrine disease, which is related to the imbalance of multiple metabolic pathways related to the secretion and action of insulin, and the metabolism of carbohydrates and lipids in the body. Correlation [1], hyperglycemia is one of its significant symptoms. There are many causes of diabetes, including life stress, diet structure, immune disorders, etc. Diabetic patients need to take drugs or inject insulin for a long time to maintain their blood sugar in an appropriate range, and bear a higher risk of complications, such as fractures, abnormal thyroid function and blood lipid levels, foot lesions, heart disease, etc. Therefore, altho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K38/28A61P3/10
CPCA61K47/6951A61K38/28A61P3/10
Inventor 张丽刘群峰张锦
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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