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Bioreactor for artificial liver

A bioreactor, artificial liver technology, applied in the field of biomedicine, can solve the problems of unfavorable cultured liver cells adhere to the wall, can not improve the efficacy of liver failure and other problems

Inactive Publication Date: 2005-07-06
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, the general hollow fiber bioreactor has defects, because hepatocytes are adherent cells, and generally adherent growth can effectively exert their physiological functions
But ordinary hollow fiber reactors are not conducive to the adherent growth of cultured hepatocytes outside the tube
The above defects are the reasons why the current bioartificial liver therapy cannot improve the curative effect of liver failure

Method used

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  • Bioreactor for artificial liver
  • Bioreactor for artificial liver

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Experimental program
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Embodiment Construction

[0009] The shape of the bioreactor for the artificial liver in this embodiment is cylindrical, with a transparent plastic shell. The size is: length 10cm, diameter of cross section 2cm, volume 20ml. In actual production, it can be enlarged or reduced according to the purpose of use, and the required size can be formulated.

[0010] like figure 1 , figure 2 As shown: 1 is the blood / plasma inlet, for blood / plasma to enter the inner cavity of the hollow fiber cylindrical inner core, 2 is the blood / plasma outlet, that is, the outlet for blood / plasma to flow through the hollow fiber inner cavity, and 3 is the Preflush / hepatocyte inlet, through which the hepatocyte suspension is injected and flushed into the preflush, 4 is the preflush outlet / sampling port, that is, the outlet of the preflush during preflush and hepatocyte injection, and also the Sampling port during artificial liver treatment, 5 inside the bioreactor is wrapped with non-woven fabric, non-woven fabric is also ca...

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Abstract

The invention discloses a bioreactor for artificial liver, wherein the conventional hollow fiber inner core bioreactor is used as a basis, nonwoven fabrics are employed to enclose a plurality of hollow fiber inner cores, thus the hollow fiber inner cores can be attached to the nonwoven fabrics with the gaps sustained. The nonwoven fabric windings are arranged parallel in the cylindrical container, the nonwoven fabrics have strong affinity to hepatocyte, thus the hepatocyte is easy to be adhered to the nonwoven fabrics walls for exerting its biological functions.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a medical device, a core device used for the treatment of biological type and mixed type artificial liver-a bioreactor for artificial liver. Background technique [0002] Bioreactor is the core device of biotype and hybrid artificial liver support system, and it is the place where exogenous liver cells and patient's blood / plasma exchange substances. As a bioreactor, it must meet the following basic requirements: two-way transmission of small and medium molecular substances, immune barrier of macromolecular substances, protection of liver cell activity and function, and a certain capacity. [0003] Existing bioreactors used in artificial livers are generally hollow fiber reactors for cell culture. The so-called hollow fiber reactor is to seal a bunch of hollow fibers in a container (generally cylindrical), the hollow fibers divide the container into two chambers, the inner cham...

Claims

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Application Information

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IPC IPC(8): A61B17/00A61D1/00A61F2/00A61M1/18C12N3/00
Inventor 李兰娟章益民李君杜微波
Owner ZHEJIANG UNIV
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