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Method and packaging for pressurized containers

A technology for pressurized containers and packaging, applied in the directions of transportation and packaging, chemical instruments and methods, containers, etc., which can solve problems such as restrictions

Inactive Publication Date: 2010-11-03
AVENTIS PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Furthermore, the ability of the packages disclosed in US 6,179,118B1, 6,119,853 and 6,352,152 to prevent the accumulation of gas within the package can be limited by the permeability of the packaging material to the propellant and the rate at which the propellant is released from the container

Method used

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  • Method and packaging for pressurized containers
  • Method and packaging for pressurized containers
  • Method and packaging for pressurized containers

Examples

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Embodiment Construction

[0014] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0015] (1) In a first embodiment of the present invention there is provided a method of maintaining the enclosed space of a hermetically sealed package at around ambient pressure, wherein the package comprises a pressurized MDI (Metered Dose Inhaler) container containing a drug, and a drug selected from the group consisting of HFA134a, A HFA (hydrofluoroalkane) propellant of HFAp227 or a mixture thereof, wherein the method comprises the steps of:

[0016] (i) placing an effective amount of HFA adsorbent material and said pressurized container in a sealable package;

[0017] (ii) The package is hermetically sealed so that the pressurized container and adsorbent are in the enclosed space within the package at a pressure approximately equal to ambient pressure;

[0018] (iii) Adsorb any outgassing of the HFA propellant in the HFA sorbent to keep the enclosed space at around ambient pressure.

[0019] (2) In another embod...

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Abstract

A method for maintaining the enclosed volume of a sealed package at about ambient pressure, wherein the package contains a pressurized container comprising a drug, and an HFA (hydrofluoroalkane) propellant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof; wherein the method comprises the steps of (1) positioning an effective amount of a HFA adsorbent material, andsaid pressurized container, within a sealable package; (2) sealing the package so that the pressurized container and adsorbent are in an enclosed volume within the package at a pressure equal to about ambient pressure; and (3) adsorbing any leakage of the HFA propellant into the HFA adsorbent material so as to maintain the enclosed volume at about ambient pressure.

Description

field of invention [0001] The present invention relates to methods and packages for packaging pressurized containers suitable for relatively long-term storage. More specifically, the present invention relates to packaging and packaging methods that utilize HFA adsorbent materials (eg, molecular sieves) to absorb or adsorb propellant gas that gradually escapes from a pressurized container, thereby preventing the propellant gas from expanding the package. Background of the invention [0002] Pressurized containers such as inhalers need to be packed in airtight packaging to prevent the ingress of ambient moisture. The use of such airtight packages can result in the accumulation of propellant gas that gradually escapes from the pressurized container, eventually leading to failure of the package's seal. This problem is exacerbated when hydrofluoroalkane propellants (eg, HFA-134a and HFA-227) are used to replace traditional propellant chlorofluorocarbons for environmental reasons...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M15/00B65D81/26B65D75/26A61J1/14A61K9/72A61K47/02A61K47/08B32B15/09B65D65/40
CPCA61M2202/062B65D75/26A61M15/009B65D81/268A61M2209/06B65D81/20B65D81/26B65D1/09
Inventor F·C·巴克尔
Owner AVENTIS PHARMA LTD