Toad cake freeze dried powder injection agent and its preparation method

A technology for freeze-dried powder injection and toad venom, which is applied in the field of freeze-dried toad venom injection and preparation thereof, can solve the problems such as no report of freeze-dried powder injection of toad venom, and achieves good pharmacological action and less irritating effects

Inactive Publication Date: 2005-10-26
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the data search, no reports were found about Chansu freeze-dried powder injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] (1) Raw drug: toad venom 2g.

[0118] (2) Take toad venom, crush it through a 20-mesh sieve, add 80% ethanol to reflux for extraction for 3 hours, recover ethanol from the reflux liquid under reduced pressure, concentrate it, and dry it in vacuum to obtain the extract of toad venom.

[0119] (3) The toad venom extract is clathrated with HP-β-CD using a saturated aqueous solution method: HP-β-CD is added with water at a ratio of 20ml / g-30ml / g, heated to dissolve, cooled to room temperature, according to the toad venom extract: The ratio of HP-β-CD=1:10 (v / g) was added to the toad venom extract, stirred for 2 hours, taken out and refrigerated for 20 hours, suction filtered, and the filter residue was dried at room temperature for 36 hours to obtain 10 g of inclusion complex of toad venom extract.

[0120] (4) Prescription of preparation: 10 g of clathrate of toad venom extract, 30 g of mannitol.

[0121] (5) Mix the inclusion compound of the above-mentioned toad venom ex...

Embodiment 2

[0123] (1) Raw drug: toad venom 2g.

[0124] (2) Take toad venom, crush it through a 30-mesh sieve, add 85% ethanol to reflux for extraction for 4 hours, recover ethanol from the reflux liquid under reduced pressure, concentrate, and vacuum dry to obtain toad venom extract.

[0125] (3) The toad venom extract is clathrated with HP-β-CD using a saturated aqueous solution method: HP-β-CD is added with water at a ratio of 20ml / g-30ml / g, heated to dissolve, cooled to room temperature, according to the toad venom extract: HP-β-CD=1:20 ratio (v / g) was added to the toad venom extract, stirred for 2-4 hours, taken out and refrigerated for 20 hours, suction filtered, and the filter residue was dried at room temperature for 36 hours to obtain the inclusion complex of toad venom extract 31g.

[0126] (4) Preparation prescription: 31 g of clathrate of toad venom extract, 49 g of glucose.

[0127] (5) Mix the inclusion compound of the above-mentioned toad venom extract with mannitol, add...

Embodiment 3

[0129] (1) Raw drug: toad venom 2g.

[0130] (2) Take toad venom, crush it through a 40-mesh sieve, add 90% ethanol to reflux for extraction for 4 hours, recover ethanol from the reflux liquid under reduced pressure, concentrate, and vacuum dry to obtain toad venom extract.

[0131] (3) The toad venom extract is clathrated with HP-β-CD using a saturated aqueous solution method: HP-β-CD is added with water at a ratio of 20ml / g-30ml / g, heated to dissolve, cooled to room temperature, according to the toad venom extract: The ratio of HP-β-CD=1:30 (v / g) was added to the toad venom extract, stirred for 4 hours, taken out and refrigerated for 20 hours, filtered with suction, and the filter residue was dried at room temperature for 36 hours to obtain 45 g of inclusion complex of toad venom extract.

[0132] (4) Preparation prescription: 45g of clathrate of toad venom extract, 55g of dextran.

[0133] (5) Mix the inclusion compound of the above-mentioned toad venom extract with dextra...

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Abstract

A freeze-dried powder injection of toad venom is prepared from the extract of toad venom, HP-beta-CD and medicinal auxiliary.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a toad venom freeze-dried powder injection and a preparation method thereof. Background technique [0002] Venenuum Bufonis is the dry secretion of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider, Bufo bufo gargarizans Cantor. Venenuum Bufonis is derived from "Materia Medica Yanyi". Detoxification, pain relief, resuscitation, refreshing and other functions. For carbuncle furuncle, sore throat, heat stroke, coma, abdominal pain, vomiting and diarrhea, it is widely used clinically to treat various cancers, tuberculosis, heart disease, malignant blood diseases, intractable hiccups, periodic facial paralysis, acute pharyngitis It can also be used for local anesthesia, topical anesthesia and painless pulpectomy for chronic pulpitis. Because of its strong pharmacological activity and wide range of effects, it has already attracte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/65
Inventor 张海峰
Owner 张海峰
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