Method for preparing aqueous solution of complex of baicalin zinc

A technology of baicalin and complexes, which is applied in the field of pharmaceutical solutions prepared with baicalin zinc complexes, can solve problems such as inconvenient use, and achieve the effect of clear appearance

Inactive Publication Date: 2005-11-16
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Not easy to use in clinical practice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Weigh 1.0g of baicalin zinc, add 37.0ml of pure water, stir in a 100ml beaker, the pH value is 5.5, and heat to 60°C; keep stirring, add 1.4ml of 2N NaOH aqueous solution drop by drop, the baicalin zinc gradually dissolves, and the pH after complete dissolution The value is 10.1, cooled to room temperature; take 0.4ml of 2N HCl, add it dropwise to the beaker under vigorous stirring, the pH value is 7.2, there is no suspension and sediment. Then the volume of the solution was adjusted to 50ml, and pure water was added. This solution namely concentration is 2% baicalin zinc aqueous solution. Appearance dark brown, clear, transparent, high viscosity.

[0009] This scheme can prepare baicalin zinc aqueous solution within 5% or higher concentration.

Embodiment 2

[0011] Weigh 5.0 g of zinc baicalin, add 25 ml of absolute ethanol and 12 ml of pure water into a 100 ml beaker and stir until the pH value is 4.0, and heat to 60°C. Take 6.9ml of 2N NaOH aqueous solution, keep stirring, add dropwise to the beaker, the baicalin zinc gradually dissolves, and the pH value after complete dissolution is 10.4, and cool to room temperature. Take 2.0ml of 2N HCl, and add it dropwise into the beaker under vigorous stirring, so that the pH value is 7.2. The volume of the solution was adjusted to 50ml, and pure water was added. That is, the concentration of baicalin is 10%, and the volume ratio is 50% ethanol solution. Appearance dark brown, clear, transparent, low viscosity.

[0012] In this scheme, adjusting the proportion of ethanol can prepare solutions with different volume ratios. By adjusting the ratio of baicalin zinc, ethanol solution of baicalin zinc with a concentration of more than 10% can be prepared.

Embodiment 3

[0014] Weigh 1.0 g of zinc baicalin and add 35 ml of pure water into a 100 ml beaker and stir until the pH value is 5.0. Take 6.9ml of 2M NaCO aqueous solution, add it dropwise into the beaker, and keep stirring, the baicalin zinc gradually dissolves, the pH value after complete dissolution is 10.2, and the dosage is about 3.2ml. Take 2N HAc, add it dropwise into the beaker with vigorous stirring, the pH value is 7.0, the amount of 2N HAc is about 3.5ml. Pure water was added, and the volume of the solution was adjusted to 50ml. This is the concentration of 2% zinc baicalin aqueous solution. Appearance dark brown, clear, transparent, high viscosity.

[0015] This scheme can prepare baicalin zinc aqueous solution within 5% or higher concentration.

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Abstract

A medical aqueous (or alcoholic) solution of baicalin zinc complex is prepared through dissolving the baicalin zinc in the alkali solution of sodium hydroxide (or carbonate), and regulating pH value by hydrochloric acid or acetic acid.

Description

Technical field [0001] The invention belongs to the medicinal solution prepared with baicalin zinc complex. Background technique [0002] The complex product of baicalin and zinc ions is called baicalin zinc for short, and its molecular structure contains acetate group, which is an acidic substance. The determination of the solubility of baicalin zinc in water and ethyl acetate shows that the water solubility and fat solubility of baicalin zinc are small. The patent application number is 99114810.X, a new drug baicalin zinc, which is brown powder and insoluble in water or ethanol. If used, it needs to be heated in a sodium carboxymethylcellulose water bath, then add glycerin and TW80, add zinc baicalin and stir evenly, spread it on a glass plate to form a film, and dry it at 70-80°C to obtain a drug film. It is not convenient to use in clinical practice. Therefore, to apply baicalin zinc powder to industries such as medicine or food, it is also...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048
Inventor 田长富刘旭陈亚娟
Owner KUNMING MEDICAL UNIVERSITY
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