Cleaning production method of raw drug N-trimethyl lysine and application method

Abstract

The invention discloses a method for the clean production of N-trimethyllysine and method of application, wherein the production method consists of screening and protecting alpha-amino with metallic ions, carrying out epsilon-amino reaction between dimethyl carbonate, an environment-friendly type methylating reagent with lysine, obtaining quaternized lysine derivative (N-trimethyllysine metallic complex), finally de-screening the metallic ions with amino carboxyl chelating agent, then isolating and purifying with ion exchange process so as to obtain medicinal grade of N-trimethyllysine, which can be used as the raw material for medicament for preventing or treating high blood pressure, lowering blood fat, maintaining blood vessel, or as food, health product additives.

Description

Technical field:

[0001] The invention relates to a clean production method of laminine, in particular using non-toxic and environment-friendly chemical raw materials and modern ion exchange technology in the whole preparation process of N-trimethyl lysine, which not only ensures the N-trimethyl lysine The quality requirements of base lysine as a pharmaceutical or food additive, at the same time, it truly ensures that N-trimethyl lysine is a green product. N-trimethyllysine can be used not only as an API for preventing cardiovascular and cerebrovascular diseases, but also as an additive for food and health care products. Background technique:

[0002] Kelp is a well-known edible algae that is rich in nutrients. Kelp contains a non-protein amino acid with special physiological function, namely N-trimethyl lysine. Because kelp is another name for kelp, N-trimethyl lysine is also called laminine. N-trimethyllysine has a special blood pressure lowering effect, which can prevent...

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