Miglinon drops and preparing method thereof

A technology of dropping pills and formulations, which is applied in the field of new pharmaceutical preparations and can solve problems such as lowering blood sugar levels

Inactive Publication Date: 2006-08-16
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results show that the drug can significantly reduce the blood sugar level of the drug users after breakfast, and also improve the patient's blood sugar level throughout the day, and no obvious adverse effects (such as hypoglycemia, etc.) have occurred

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] prescription:

[0019] Miglinide 0.5g

[0020] PEG4000 4.5g

[0021] PEG9000 25g

[0022] A total of 1000 capsules were made

[0023] Preparation:

[0024] Take mitiglinide, PEG4000, and PEG9000 and mix them evenly, heat them in a water bath to melt them completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, select the dripper, and drop Put it into simethicone oil at -5°C, and after it is formed, filter, separate, and wipe it clean.

Embodiment 2

[0026] prescription:

[0027] Miglinide 1g

[0028] PEG6000 25g

[0029] Polyoxyl 40 Stearate 24g

[0030] A total of 1000 capsules were made

[0031] Preparation:

[0032] Mix Miglinide, PEG6000, and polyoxyl 40 stearate evenly, and heat in a water bath to melt completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dropping pill making machine, and keep it warm at 80°C , select the dripper, drop it into the simethicone oil at -10°C, after it is formed, filter, separate, and wipe it clean.

Embodiment 3

[0034] prescription:

[0035] Miglinide 1g

[0036] Polyoxyl 40 Stearate 244g

[0037] A total of 1000 capsules were made

[0038] Preparation:

[0039] Take mitiglinide and polyoxyl 40 stearate and mix evenly, heat in a water bath to melt completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dropping pill dropping machine, keep it warm at 80°C, and select The dripper is dropped into the liquid paraffin at -5°C, and after being shaped, it is filtered, separated, and wiped clean.

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PUM

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Abstract

A dripping pill of miglinar for treating hepatitis B and its preparing process are disclosed. Its advantages are high disintegrating speed and biologic utilization rate, and simple preparing process.

Description

technical field [0001] The invention relates to a novel pharmaceutical preparation, in particular to mitiglinide dripping pills for treating hepatitis B and a preparation method thereof. Background technique [0002] Diabetes mellitus (Diabetes mellitus) is a syndrome of glucose, protein and lipid metabolism disorders caused by insulin deficiency or insulin cell metabolism defects. Proper control can lead to chronic complications in tissues and organs such as eyes, kidneys, nerves, blood vessels, and heart, and eventually lead to blindness, lower limb gangrene, uremia, cerebral apoplexy or myocardial infarction, and even life-threatening. Diabetes is a common disease. With the improvement of living standards, the incidence of diabetes is increasing year by year. The prevalence of diabetes in developed countries has reached 5%-10%, and the prevalence in my country has reached 3%. [0003] Miglinide is the third meglitaide drug after repaglinide and nateglinide, and it is a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4035A61K9/20A61P3/10A61P1/16A61P31/12
Inventor 严轶东
Owner FUKANGREN BIO PHARMA
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