Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

A technology of hematopoietic stem cells and stem cells, which is applied in the treatment of ocular vascular diseases and the field of hematopoietic stem cell groups, can solve the problems of uncertain cell number and unclear mechanism, and achieve the effect of protecting retinal neurons and photoreceptors
CN1831119AInactive Publication Date: 2006-09-13THE SCRIPPS RES INST
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE SCRIPPS RES INST
Publication Date
2006-09-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

Isolated, mammalian, adult bone marrow-derived, lineage negative hematopoietic stem cell populations (Lin - HSCs) containing endothelial progenitor cells (EPCs) have been transfected with therapeutically useful genes. The transfected isolated stem cell populations of the invention are useful for delivering genes to the eye for cell-based gene therapy. Methods of preparing transfected isolated stem cell populations of the invention, and methods of treating ocular diseases and injury are also described.
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Description

[0001] This application is a divisional application of an invention patent application whose application date is April 28, 2004, and whose application number is 200480018990.6, and whose invention name is the same as that of the present invention.

[0002] Cross References to Related Applications

[0003] This application is a continuation-in-part of U.S. Patent Application 10 / 628,783, filed July 25, 2003, a provisional application claiming 60 / 398,522, filed July 25, 2002, and 60 / 467,051, filed May 2, 2003 The entire disclosure content of the above-mentioned application is incorporated into this application by reference.

[0004] Statement of Government Interest

[0005] Part of the work described herein was supported by National Cancer Institute grant CA92577 and National Institutes of Health grants EY11254, EY12598, and EY125998. The US Government has certain rights in this invention. technical field

[0006] The present invention relates to isolated, mammalian, lineage-n...

Claims

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