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Quick detection reagent for syphilis leptospira antigen and preparation method thereof

A technology of Treponema pallidum and detection reagents, which is applied in the fields of microbiology and immunology, can solve the problem of not being able to distinguish past infection from current infection, etc., and achieve the effect of simple and fast detection, high sensitivity, and wide application

Inactive Publication Date: 2006-11-22
吴学记
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Problems solved by technology

However, the current general blood test mainly detects syphilis antibodies and cannot distinguish between past infection and current infection

Method used

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  • Quick detection reagent for syphilis leptospira antigen and preparation method thereof
  • Quick detection reagent for syphilis leptospira antigen and preparation method thereof
  • Quick detection reagent for syphilis leptospira antigen and preparation method thereof

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Embodiment Construction

[0016] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments.

[0017] Rapid diagnostic test strip technology is a new in vitro diagnostic technology developed on the basis of monoclonal antibody technology, colloidal gold immunochromatography technology and new material technology since the 1990s. In recent years, this technology has developed rapidly and has been widely used in the early diagnosis and early detection of diseases in the field of biomedicine, especially in medical testing. The present invention is prepared by using purified nitrocellulose membrane coated with anti-Treponemal pallidum monoclonal antibody and freeze-dried gold-labeled anti-Treponema pallidum monoclonal antibody, using colloidal gold immunochromatography technology, and specificity in the way of double-antigen sandwich Detection of Treponema pallidum or its fragments in body fluids, secretions, cultures.

[0018] refer to f...

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Abstract

The related fast detection agent for syphilis spirochete antibody comprises a fast detection paper prepared by cellulose nitrate covered by pure syphilis spirochete monoclonal antibody and dried gold-mark monoclonal antibody. Wherein, with colloid gold immune chromatography technology and double antigen sandwich way, detecting syphilis spirochete and its fragment in humor, secretion and culture. This invention has more clinic meaning, high specificity, well sensitivity, and fit to wide spread.

Description

technical field [0001] The invention belongs to the field of microbiology and immunology, and relates to a microbial detection composition and a method thereof, in particular to a rapid detection reagent for Treponema pallidum antigen and a preparation method thereof. Background technique [0002] The pathogen that causes syphilis is Treponema pallidum, which was first discovered by Schandim and Hoffman in 1905. Treponema pallidum is about 6 to 15 microns long and 0.1 to 0.25 microns wide, in a spiral shape. When not affected by external factors, the spiral is regular. After this pathogen enters the human body through mucous membranes or damaged skin, it can reproduce in two in the human body in the form of transverse division for a long time. It can spread to the whole body through the lymphatic system and blood circulation, and can almost invade all organs and tissues of the whole body. If the infection is not treated initially, most patients develop the chronic phase of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/558G01N33/532G01N33/543G01N33/577
Inventor 吴学记
Owner 吴学记
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