Preparation of depressor peptide by silkworm chrysalis

Abstract

The present invention discloses a method of preparing antihypertensive peptide from silkworm pupa which includes the following steps: the defatted dry powder of silkworm pupa or silkworm pupa protein powder is mixed with water at the mass ratio of 1:6-7, the pH value is adjusted to 6.0-6.5, then neutral proteinase is added for hydrolysis at 50-55DEG C for 120-200 minutes, the result hydrolysate is antihypertensive peptide. The weight of the said neutral proteinase is 0.9-1.1% of the defatted dry powder of silkworm pupa or silkworm pupa protein powder. The method in the present invention that utilizes silkworm pupa to prepare antihypertensive peptide has lower cost and better effect.

Description

technical field

[0001] The invention belongs to the technical field of bioengineering, and in particular relates to a method for preparing hypotensive peptides by using silkworm chrysalis. Background technique

[0002] Angiotensin-converting enzyme (ACE) plays an important role in blood pressure regulation. Angiotensin-converting enzyme (ACE) inhibitory active peptide is a kind of angiotensin-converting enzyme inhibitor (ACEI), which can lower blood pressure by inhibiting the activity of ACE. There are many kinds of chemically synthesized peptide drugs as ACE inhibitors. The disadvantage of this kind of synthetic antihypertensive drugs is that the action time is not long, the blood pressure is easy to rebound, and the drugs are easily excreted by the kidneys to cause damage to renal function.

[0003] Extracting functional peptides with nutritional and physiological activities from natural proteins, and applying these functional peptides to health food and fortified nutrit...