New application of rhubarb stilbene glucoside

A technology of trizastilbene and its use, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, antiviral agents, etc.

Pending Publication Date: 2022-05-27
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since SARS-CoV-2 is different from any pathogen that humans have ever seen, it is difficult to have a clear understanding of it. Therefore, understanding the inherent pathophysiological mecha

Method used

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  • New application of rhubarb stilbene glucoside
  • New application of rhubarb stilbene glucoside
  • New application of rhubarb stilbene glucoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Study on the inhibitory effect on ACE

[0050] In this experiment, the protein with the protein sequence of Abz-SDK(Dnp)P-OH was used as the substrate of ACE, and when it was combined with ACE, a fluorescent group was released. The average speed of fluorescence generation was detected by a microplate reader, which could reflect the activity of ACE . The test substances were formulated into different concentrations, added to the reaction system according to Table 1, the average reaction rate was measured at a wavelength of 460 nm, and the inhibition rate of each test substance was calculated. Three wells were repeated for each concentration, and the results were averaged.

[0051] (1) Test product

[0052] rhubarb aglycin-3`-O-β-D-glu: off-white powder;

[0053] Deoxy-emodin: lilac crystalline powder;

[0054] Resveratrol: white fine crystalline powder;

[0055] Polygoniside: pale yellow powder;

[0056] Picclitaxel: powdery white powder;

[0057] Trist...

Embodiment 2

[0097] Example 2: Effects on nephritis rats

[0098] (1) Experimental materials

[0099] 1.1 Sample

[0100] 1.1.1 Test substance

[0101] Tristilbeneside for injection: 20mg / piece, provided by the Institute of Pharmaceutical Research of Kunming Pharmaceutical Group.

[0102] 1.1.2 Positive control

[0103] Benazepril hydrochloride tablets (Luotingxin), approved by Chinese medicine H20030514, 10mg / tablet, produced by Beijing Novartis Pharmaceutical Co., Ltd., batch number X1774; during the experiment, 1% CMC-Na was used to prepare a suspension with a concentration of 0.6mg / mL liquid.

[0104] 1.1.3 Vehicle control

[0105] Sodium carboxymethyl cellulose (CMC-Na), chemically pure, 500g / bottle, Sinopharm Chemical Reagent Co., Ltd., batch number F20100909, heated, boiled and cooled with pure water to make 1% concentration, after autoclaving For the preparation of the test sample and the control of the vehicle, it is prepared once and used for 5 to 7 days.

[0106] 1.2 Animal...

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Abstract

The invention discloses a rheum lhasaense extract, and particularly relates to application of rhubarb stilbene glucoside in preparation of ACE inhibitory activity related drugs. Based on mechanism analysis of heart and kidney injury caused by SARS-CoV-2 infection, the 3, 5, 6-trihydroxy-stilbene glucoside has a potential drug acting on ACE through regulation of an RAS system and targeting, is helpful to alleviation of heart and kidney injury of COVID-19 patients, and is applied to preparation of drugs for prevention and treatment of injury of multiple organs such as heart and kidney caused by novel coronavirus pneumonia. The active ingredients of the medicine can be extracted from plants, the yield is high, the medicine can be used for industrial production, the used medicine is easy to obtain, and the market prospect is good.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new use of Lhasa rhubarb extract in medicines for damage to multiple organs such as the heart and kidney, in particular to the new use of tristilbene in the preparation of medicines for preventing and treating multiple organ damages such as the heart and kidney caused by novel coronavirus pneumonia . Background technique [0002] At present, angiotensin inhibitors (ACEI) are widely used in clinical practice, and the mechanism is that the renin-angiotensin-aldosterone system (RAAS) plays an important role in regulating nerve, endocrine and blood pressure in vivo. ACEI has the effect of reducing urinary protein and improving renal function. ACEI has also been widely used in chronic congestive heart failure, myocardial infarction, diabetes, liver injury, DN, digestive system diseases, and nervous system diseases. [0003] The new coronavirus disease 2019 (COVID-19) is caused by th...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K31/7034A61P31/14A61P9/00A61P13/12
CPCA61K36/708A61K31/7034A61P31/14A61P9/00A61P13/12
Inventor 刘一丹黄茜刘国光尚建华葛建华刘军锋
Owner KPC PHARM INC
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