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Method of vaccination against testicular BVDV infection

A vaccine and testis technology, applied in the direction of anti-infective drugs, vaccines, multivalent vaccines, etc., can solve the problems of testicular infection economy of susceptible male animals, reproductive loss of cows, impact, etc.

Inactive Publication Date: 2007-03-14
PHARMACIA & UPJOHN CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the details of transmissibility through natural breeding and impact on bull fertility have not been established, it is clear that testicular infection in susceptible males has a significant economic impact due to the reproductive loss caused by BVDV transmission to cows
[0008] Viral infection of the testis poses a significant challenge for treatment or prevention by immunization, since the testis is known to be immune-blocking

Method used

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  • Method of vaccination against testicular BVDV infection

Examples

Experimental program
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Effect test

Embodiment 1

[0090] Protection of the testicles: a research review

[0091] Bovi-Shield using Type 1 BVDV and Type 2 BVDV modulation  GOLD TM 5 vaccine line, introduced to the cattle breeding industry in November 2003, to obtain the optimum degree of embryonic protection against type 2 BVDV provided by vaccination. Reported here are the results of a pre-licensing efficacy study evaluating the use of Bovi-Shield during pre-adolescence  GOLD TM 5 Is vaccination effective in preventing severe type 2 BVDV-challenged testicular infection 10, and compared to placebo (Bovi-Shield(R) IBR-PI3-BRSV).

[0092] All steers (n=17) included in the broader type 2 BVDV challenge study were further evaluated to determine vaccination with Bovi-Shield GOLD TM 5  Is it effective in preventing testicular infection with BVDV. All calves (male and female) in the initial investigation were colostrum-weaned calves (male and female) at the age of 3 to 4 months. Use vaccines that contain the lowest immu...

Embodiment 2

[0107] Testicular protection against type 1 BVDV challenge—a research review

[0108] Research conducted to evaluate Bovi-Shield  GOLD TM 5 Efficacy in preventing testicular infection in the face of severe type 1 BVDV challenge. This study was designed as a general randomized block design (blockdesign), with a one-way treatment structure. All research personnel are blinded to processing information.

[0109] Forty-five intact beef steers near puberty were allocated for the study. Heifers are 9 months to 15 months old. All animals were seronegative for BVD virus type 1 and type 2, negative for BVD virus isolates in serum, and negative for reverse transcription nested polymerase chain reaction (RT-nPCR) in serum. On Day 42, the minimum mean square body weights of steers in the placebo group (n=23) and the test group (n=22) were 625.7±30.94 lbs and 613.5±35.96 lbs, respectively. Animals were inoculated with placebo (Bovi-Shield  IBR-PI3-BRSV) or Bovi-Shield  GOLD TM ...

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Abstract

The methods of the invention relate to methods for preventing testicular infection by bovine viral diarrhea virus by immunizing susceptible male animals against infection.

Description

technical field [0001] The present invention relates to a method of preventing testicular infection caused by bovine viral diarrhea virus by immunizing susceptible male animals against infection. Background technique [0002] Bovine viral diarrhea virus (BVDV) is an economically significant pathogen of cattle and other susceptible animals that can be shed into the semen of persistently and acutely infected bulls and other susceptible males. This pathogen causes gastrointestinal, respiratory and reproductive disorders in susceptible animals. [0003] While the gastrointestinal and respiratory disease caused by highly pathogenic strains of BVDV is clinically severe, the reproductive losses caused by BVDV are more economically significant. References to BVDV transmission have established that virus in bull semen can infect susceptible, inseminated cows, resulting in reduced conception rates, early fetal death, abortion, and birth of persistently BVDV-infected calves. 1-3 [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12A61K39/295
CPCA61K2039/70C12N2770/24334A61K2039/552A61K39/295A61K2039/5254A61K39/12A61P31/00A61P31/12A61P31/14A61P37/00
Inventor M·A·埃尔斯沃思C·M·塔克
Owner PHARMACIA & UPJOHN CO
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