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Pharmaceutical composition for treating gynecological inflammation and preparation method thereof

A technology of gynecological inflammation and composition, which is applied in the field of traditional Chinese medicine, can solve the problems of obvious side effects of antibiotics, and achieve the effect of small side effects and good curative effect

Inactive Publication Date: 2007-04-25
上海慈瑞医药科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical treatment of gynecological inflammation mainly uses large doses of antibiotics, and sometimes a combination of multiple antibiotics is required, making the side effects of antibiotics such as drug resistance and complications increasingly obvious

Method used

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  • Pharmaceutical composition for treating gynecological inflammation and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: the preparation of dropping pill

[0025] Take 1 part of Prunella vulgaris and 2 parts of eucalyptus leaves, combine and pulverize them, put them into a supercritical fluid extraction tank, use carbon dioxide as the supercritical extraction fluid, flow 2.5 liters / min, pressure 25MPa, temperature 35°C, and time 80 minutes to obtain Prunella vulgaris and eucalyptus essential oil extract A;

[0026] Take 1 portion of honeysuckle, extract twice with 70% ethanol under reflux, add 8 times the amount of ethanol for the first time, reflux for 2 hours, pour out the extract, add 6 times the amount of ethanol for the second time, reflux for 1 hour, combine the extracts, and filter , the filtrate is decompressed, the pressure is -0.8Mpa, the ethanol is recovered and concentrated, and spray-dried to obtain the honeysuckle extract E;

[0027] Mix extract A and extract E to obtain extract E, mix extract F with dropping pill matrix polyethylene glycol 6000 in a weight ra...

Embodiment 2

[0028] Embodiment 2: the preparation of tablet

[0029] Take 1 part of Prunella vulgaris and 1 part of eucalyptus leaves, combine and pulverize them, put them into a supercritical fluid extraction tank, use carbon dioxide as the supercritical extraction fluid, flow 2.5 liters / min, pressure 25MPa, temperature 35°C, time 80 minutes, to obtain Prunella vulgaris and eucalyptus essential oil extract A;

[0030] Take 5 parts of Prunella vulgaris, decoct twice with water, add 10 times the amount of water for the first time, decoct for 1 hour, pour out the extract; add 7 times the amount of water for the second time, and decoct for 1 hour. The extracts were combined, centrifuged, and the supernatant was concentrated under reduced pressure at a pressure of -0.6Mpa, and the concentrate was vacuum-dried to obtain Prunella vulgaris Extract C;

[0031] Take 1 portion of honeysuckle, extract twice with 70% ethanol under reflux, add 8 times the amount of ethanol for the first time, reflux f...

Embodiment 3

[0033] Embodiment 3: the preparation of capsule

[0034] Take 2 parts of Prunella vulgaris and 2 parts of eucalyptus leaves, combine and crush them, put them into a volatile oil extractor, add 10 times the amount of water, pass in steam for 5 hours, collect the initial distillate, and redistill for 3 hours to obtain Prunella vulgaris and Eucalyptus Leaf volatile oil extract B;

[0035] Take 2 parts of Prunella vulgaris, decoct twice with water, add 10 times the amount of water for the first time, decoct for 1 hour, pour out the extract, add 7 times the amount of water for the second time, decoct for 1 hour, combine the extracts, centrifuge, and take The supernatant was concentrated under reduced pressure, the pressure was -0.5Mpa, and vacuum-dried to obtain Prunella vulgaris extract C;

[0036] Take 4 parts of honeysuckle, decoct twice with water, add 9 times the amount of water for the first time, decoct for 1 hour, add 7 times the amount of water for the second time, decoct...

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Abstract

The invention relates to a medicinal composition for treating gynaecologic diseases, wherein the composition is prepared from the following raw materials (by weight portion): selfheal 1-6 parts, eucalyptus 1-5 parts, honeysuckle flower 1-4 parts, the preparing process comprises the steps of producing extracts of raw materials, mixing extracts, making various dose forms, charging pharmaceutically acceptable adjuvant or supplementary constituents to obtain clinically acceptable dose forms including tablets, capsules, dripping pills, mixtures, granules, injections, suppositories, effervescent tablets and hypodermal preparations.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gynecological inflammation and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Gynecological inflammation accounts for a large proportion of gynecological diseases, especially cervicitis, pelvic inflammatory disease, salpingitis, vulvitis and vaginitis. At present, the clinical treatment of gynecological inflammation mainly uses large doses of antibiotics, and sometimes a combination of multiple antibiotics is required, which makes the side effects of antibiotics such as drug resistance and complications increasingly obvious. Contents of the invention [0003] The purpose of the present invention is to provide a pharmaceutical composition for treating gynecological inflammation with good curative effect and little side effect and its preparation method. [0004] In order to achieve the above object, the te...

Claims

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Application Information

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IPC IPC(8): A61K36/536A61K9/02A61K9/08A61K9/16A61K9/20A61K9/48A61P15/00A61P15/02
Inventor 金幸汤磊陈林祥朱益锋付静静
Owner 上海慈瑞医药科技股份有限公司
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