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Composition of Chinese traditional medicine, preparation method, and quality control method

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve problems such as not seen, and achieve the effects of reducing the number of writhing times, prolonging the latency period of the pain threshold, and enhancing the transformation function of lymphocytes

Active Publication Date: 2007-05-09
CHENGDU HUASUN GRP INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] To sum up, although there are many Chinese patent medicines currently available for the treatment of common colds, there are many types of syndromes to be treated, but in the treatment of wind-heat colds, Chai Ge is used for the treatment of the surface, instead of silver root orchids, and it is used for the treatment of internal heat. There is no known patent medicine of rhubarb that uses Scutellaria baicalensis instead of heat-clearing and purging

Method used

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  • Composition of Chinese traditional medicine, preparation method, and quality control method
  • Composition of Chinese traditional medicine, preparation method, and quality control method
  • Composition of Chinese traditional medicine, preparation method, and quality control method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0039] Experimental example 1 Research on the technical conditions of the extraction process of the pharmaceutical composition of the present invention

[0040] 1. Selection of extraction solvent and concentration:

[0041] The main active ingredients in the formula are flavonoids and saponins, which can be dissolved in water and ethanol. The solvent and its concentration are the most important factors affecting the extraction effect. In order to extract the active ingredients as completely as possible, the following experiments were designed with the total flavonoids, total saponin yield, and pharmacodynamic antipyretic effect as the investigation indicators:

[0042] According to the proportioning relationship of 5 parts by weight of Bupleurum, 4 parts by weight of Scutellaria baicalensis, 4 parts by weight of Pueraria Radix, and 3 parts by weight of Glycyrrhizae, 5 parts of medicinal materials are weighed, each part is 160g, and 4 times the amount of water and different con...

experiment example 2

[0119] Experimental Example 2 Research on the separation, purification, concentration and drying process of the composition of the present invention:

[0120] 1. Research on the concentration process of the crude extract:

[0121] Take a total of 480g of the four medicinal materials in the same proportion, add 1920ml of 70% ethanol to heat and extract for 1.5 hours, extract 4 times, filter while hot, combine the filtrate, recover the solvent under reduced pressure (0.095MPa, 65°C), concentrate to 240ml, and measure the relative density It is 1.15-1.20.

[0122] Take 10ml liquid extract and dry, add 40ml distilled water, ultrasonic treatment (power 250W, working frequency 29KHz) for 10 minutes, refrigerate in refrigerator for 48 hours, vacuum filtration (0.095MPa), complete in 3 hours, insoluble solids are dried and weighed. (method one)

[0123] Take another 10ml of liquid extract, add 30ml of distilled water directly, stir, refrigerate for 48 hours, filter under reduced pre...

experiment example 3

[0148] Experimental Example 3 Screening of the present invention's capsule preparation adjuvant and its dosage

[0149] Taking the appearance and disintegration as indicators, the experiment investigated the effects of different dosages and mixing ratios of three excipients—starch, dextrin, and β-cyclodextrin. The experiment designed 11 small sample prescriptions as shown in Table 20. .

[0150] prescription number

Medicinal extract (g)

Starch (grams)

β cyclodextrin (g)

Dextrin (g)

1

2

3

4

5

6

7

8

9

10

11

20

16

16

16

16

16

16

14

12

10

8

0

4

0

0

2

2

0

0

0

0

0

0

0

4

0

2

0

2

0

0

0

0

0

0

0

4

0

2

2

6

8

10

12

[0151] Weigh the medicine and auxiliary materials according to the prescription amount in the...

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Abstract

A Chinese medicine for treating cold is proportionally prepared from bupleurum root, scutellaria root, pueria root and liquorice root. Its preparing process and its quality control method are also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and a quality control method thereof, in particular to a traditional Chinese medicine composition for treating cold with exogenous wind-heat syndrome, a preparation method and a quality control method thereof, belonging to the technical field of medicine. Background technique [0002] Cold in Chinese medicine includes various infectious diseases of the upper respiratory tract in Western medicine, such as influenza, acute inflammation of the upper respiratory tract caused by viral and bacterial infections, etc. It is a very common clinical syndrome, and it is easy to delay or improper treatment Cause a variety of other secondary symptoms. It has adverse effects on people's work and life. [0003] Chinese medicine is a great treasure house. Although cold is only one disease in Chinese medicine, it has different classifications. The treatment also has its own characteristics. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P31/00A61P11/00G01N30/02G01N33/15
Inventor 杨世林徐丽珍任明非万方王卫华
Owner CHENGDU HUASUN GRP INC LTD
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