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Rue family citrus plant pericarp extract, preparation method and use thereof

A technology of peel extract and citrus, which is applied in the field of peel extract of citrus plants of Rutaceae, can solve problems such as unreported effects of UVA zone, and achieves a technology that is convenient for industrialized large-scale production, low in cost, and inhibits skin damage. Effect

Inactive Publication Date: 2010-04-28
CHENGDU WAGOTT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, although it has been reported that nobiletin can inhibit the pigmentation and aging caused by the UVB area, it has not been reported that it has an effect on the UVA area

Method used

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  • Rue family citrus plant pericarp extract, preparation method and use thereof
  • Rue family citrus plant pericarp extract, preparation method and use thereof
  • Rue family citrus plant pericarp extract, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 Preparation of the extract of the present invention

[0027] 200g citrus peel coarse powder, extract three times with 60% ethanol, combine the extracts, filter, concentrate the extracts until the alcohol content reaches 30%, concentrate the filtrate until it has no alcohol smell, apply macroporous adsorption resin, wash with water until the color becomes lighter, When clear, elute with 2000ml70% ethanol, after the eluate is concentrated and dried, add No. 6 solvent oil for degreasing, and the content of 4g is 30.5% (as determined by HPLC), which is the sum of nobiletin and tangeretin.

Embodiment 2

[0028] Embodiment 2 Preparation of the extract of the present invention

[0029] 200g citrus peel coarse powder, extract with 80% ethanol, reflux extraction twice, combine the extracts, filter, concentrate the extracts until the alcohol content reaches 40%, concentrate the filtrate until there is no alcohol smell, put on a macroporous adsorption resin, wash with water until When the color becomes lighter and clear, elute with 2000ml of 70% ethanol, and after the eluate is concentrated and dried, add petroleum ether to degrease, and the content of 3g is 50.6% (as determined by HPLC), and the content values ​​are nobiletin and orange peelin of and.

Embodiment 3

[0030] Embodiment 3 Preparation of the extract of the present invention

[0031] 200g citrus peel coarse powder, reflux extraction with 70% ethanol three times, combine the extracts, filter, concentrate the extracts until the alcohol content reaches 60%, concentrate the filtrate until it has no alcohol smell, apply macroporous adsorption resin, wash with water until the color becomes lighter , when clear, first elute with 500ml 50% ethanol, then elute with 90% ethanol, after the 90% eluate is concentrated and dried, add sherwood oil to degrease, and the content of 1.3g is 79.8% (measured by HPLC). The content value is the sum of nobiletin and tangeretin.

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Abstract

The invention relates to a Rutaceae citrus reel extractive, which uses the reel of Rutaceae citrus plant as material, wherein the contents of nobiletin and tangeretin are 30-80%. The invention also provides a method for using said extractive to prepare cosmetics, which has constant sun-screening effect in UVA and UVB areas, to avoid ultraviolet light to hurt skin.

Description

technical field [0001] The invention provides a fruit peel extract of Rutaceae citrus plants, which belongs to the field of pharmaceutical daily chemical industry. Background technique [0002] The skin is located on the surface of the body and is the body's first line of defense. Ultraviolet radiation can damage the skin, such as sunburn, skin darkening, skin photoaging, skin photosensitivity and even skin cancer, so strengthening the research on ultraviolet protection has become a hot topic since the new century. The wavelength range of ultraviolet light is generally 100-400nm, which can be divided into three bands: long-wave ultraviolet (UVA), wavelength 320-400nm; medium-wave ultraviolet (UVB), wavelength 290-320nm; short-wave ultraviolet (UVC), wavelength 100nm ~280nm. Since UVC is completely absorbed by the atmospheric ozone layer, only UVB and UVA from solar radiation can reach the surface of the earth. Therefore, the main effect of sunscreen products is reflected ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K36/752A61Q17/04
Inventor 袁宙张燕周开静
Owner CHENGDU WAGOTT PHARMA
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