Chinese medicinal composition for resisting hepatic fibrosis and method for preparing same

An anti-liver fibrosis and composition technology, which is applied in the field of preparation of traditional Chinese medicine compositions, can solve the problems of limited curative effect of viral liver fibrosis, weak anti-viral power and the like, and achieves full scientificity and feasibility and remarkable curative effect. , the exact effect of curative effect

Active Publication Date: 2007-05-23
JIANGSU TIANZHAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Dahuang Zhechong Pill has a strong effect of promoting blood circulation and removing blood stasis, most of the prescriptions are composed of worm-like blood-breaking drugs, which are more powerful and have weak anti-viral power, so the therapeutic effect on viral liver fibrosis is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Embodiment 1, anti-hepatic fibrosis Chinese medicine composition and preparation method thereof:

[0078] Take raw materials, 530g of ants, 180g of salvia miltiorrhiza, 340g of sophora flavescens, 260g of astragalus, 180g of ground beetle (or expand in the same proportion);

[0079] Among them, the ants and ground beetles are crushed into coarse powder, soaked in 6-12 times the amount of water (containing 0.1% sodium benzoate), stirred until homogenized, and the homogenized solution is placed in a constant temperature water bath (35-37°C), stirred (80-37°C) 150 rpm) for 8 to 16 hours, centrifuge, discard the precipitate, take the centrifuged liquid and pre-filter it through a 1 μm pore size membrane, filter the filtrate through a 0.2 μm pore size membrane to sterilize, and then pass the sterilized filtrate through an ultrafilter (cut-off molecular section 6000-10000), the ultrafiltration concentration is about 1:0.5-1.5 (that is, the volume ratio of the medicinal materi...

Embodiment 2

[0080] Embodiment 2 is substantially the same as Embodiment 1, but the ratio of each component of its raw material is:

[0081] Ant 500g Salvia 160g Sophora 320g

[0082] Astragalus 240g Wood Beetle 160g.

[0083] At the same time, the following changes are made:

[0084] When the sterilized filtrate of ants and ground beetles passes through the ultrafilter, the cut-off molecular segment is 3000-10000;

[0085] The preservative was changed to sorbitol;

[0086] The extraction process of Salvia miltiorrhiza, Sophora flavescens and Radix Astragali is as follows: fractional precipitation with 30%, 50%, and 80% ethanol for several times, separate and combine the precipitates, and dry them into powder; the drying method is changed to spray drying.

Embodiment 3

[0087] Embodiment 3 is substantially the same as embodiment 1 or 2, but the ratio of each component of its raw material is:

[0088] Ant 560g Salvia 200g Sophora 360g

[0089] Astragalus 280g Wood Beetle 200g.

[0090] At the same time, the following changes are made:

[0091] When the sterilized filtrate of ants and ground beetles passes through an ultrafilter, the cut-off molecular segment is 6000-20000.

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Abstract

The invention relates to a traditional composite which can prevent liver fibrosis, wherein it comprises 500-560g ant, 160-200g Danshen, 320-360g kuh-seng, 240-280g milk vetch root, 160-200g soil insect, or at other ratio. It uses the extractive of ant and soil insect; breaks, immerges in water, mixing into slurry, constant-temperature mixing, eccentrically filtering, passing eccentric liquid through 1 mum-porous film, 0.2 mum-porous film, filtering and disinfecting, passing through ultra-filter to stop the molecules at 3000-20000, concentrating, drying into powder; the Danshen, kuh-seng and milk vetch root are extracted via alcohol, to be concentrated, dried into powder; or using alcohol to deposit and extract, drying into powder. The invention can kidney tonifying, activate blood circulation and remove stasis, etc.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for resisting liver fibrosis and a preparation method of the traditional Chinese medicine composition. Background technique [0002] Liver fibrosis is a common tissue change in various chronic liver injuries (viruses, alcohol, parasitic infections, metabolic diseases, etc.), and is the only way for chronic liver diseases to develop into cirrhosis. Liver fibrosis is generally caused by hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV), especially hepatitis B virus. my country is a high-incidence area of ​​hepatitis B virus infection, the adult hepatitis B virus infection rate is 42.4% to 80.77%, and the hepatitis B surface antigen (HBsAg) carrier is 10.7%. According to foreign reports, about 5% to 10% of acute hepatitis B develops into chronic hepatitis, and domestic reports are as high as 24% to 50%. The incidence rate of chronic hepatitis is more than 100 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/48A61P1/16A61K35/64
Inventor 张文鹄夏培元储益平陆赛卫
Owner JIANGSU TIANZHAO PHARMA
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