Method for detecting blood concentration of multiple antiepileptic drugs simultaneously
An anti-epileptic drug and blood drug concentration technology, applied in the field of medical testing, can solve the problems of expensive equipment or reagents, cumbersome and time-consuming operation, and high analysis cost, and achieve the effects of simple operation, less plasma consumption and high sensitivity
Inactive Publication Date: 2007-05-30
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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Problems solved by technology
The method in the prior art has various defects such as cumbersome and time-consuming operation, low efficiency, long measurement cycle, expensive equipment or reagents, and high analysis cost, and is not suitable for routine therapeutic drug concentration monitoring
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[0025] Chromatographic conditions
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The invention belongs to field of medical examination and relates to assay determination method of internal medicine, specially a detecting method of six antiepileptics medicines of primidone, phenylethylmalonylurea, diphenylhydantoin, carbamazepine, Larmortriazine, okazepine and the active product monohydroxy okazepine of okazepine and the active product epoxy carbamazepine of carbamazepine in human plasma. The sample to be measured is eluted equicontinuously in condition of acidic mobile phase via the pretreatment of protein precipitation, and separated by chromatographic column, and detected by ultraviolet detector. The quantity of sample in the invention is small; the pretreatment method is simple, fast and sensitive, free of expensive apparatus and agents, applicability is wide, cost is low, it fits for the detection of normal blood concentration in clinic.
Description
Technical field [0001] The invention belongs to the field of medical testing, and relates to a method for analyzing and measuring drugs in the body. Specifically, it relates to a method capable of simultaneously measuring the blood concentration of multiple anti-epileptic drugs. Background technique [0002] Primidone (Primidone, PRI), Phenobarbital (Phenobarbital, PB), Phenytoin (Phenytoin, PHT), Carbamazepine (Carbamazepine, CBZ) are traditional first-line anti-epileptic drugs, lamotrigine (Lamotrigen, LTG), Oxcarbazepine (Oxcarbazepine, OXC) are the second-generation anti-epileptic drugs marketed in the past decade. OXC and CBZ can be respectively metabolized into the active products monohydroxycarbazepine (MHD) and carbamazepine (Carbamazepine 10, 11-epoxide, CBZE) in the body. Because the pharmacokinetics of these drugs vary greatly among individuals, the therapeutic window is narrow, and the pharmacokinetic properties are related to the anti-epileptic effect and the occurre...
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IPC IPC(8): G01N33/02G01N33/06G01N33/15
Inventor 焦正施孝金
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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