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Method for detecting blood concentration of multiple antiepileptic drugs simultaneously

A technology of antiepileptic drugs and blood drug concentration, which is applied in the field of medical testing, can solve the problems of expensive equipment or reagents, cumbersome and time-consuming operations, and high analysis costs, and achieve the effects of simple operation, less plasma consumption, and high sensitivity

Inactive Publication Date: 2010-11-24
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method in the prior art has various defects such as cumbersome and time-consuming operation, low efficiency, long measurement cycle, expensive equipment or reagents, and high analysis cost, and is not suitable for routine therapeutic drug concentration monitoring

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  • Method for detecting blood concentration of multiple antiepileptic drugs simultaneously

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Embodiment 1

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Abstract

The invention belongs to field of medical examination and relates to assay determination method of internal medicine, specially a detecting method of six antiepileptics medicines of primidone, phenylethylmalonylurea, diphenylhydantoin, carbamazepine, Larmortriazine, okazepine and the active product monohydroxy okazepine of okazepine and the active product epoxy carbamazepine of carbamazepine in human plasma. The sample to be measured is eluted equicontinuously in condition of acidic mobile phase via the pretreatment of protein precipitation, and separated by chromatographic column, and detected by ultraviolet detector. The quantity of sample in the invention is small; the pretreatment method is simple, fast and sensitive, free of expensive apparatus and agents, applicability is wide, costis low, it fits for the detection of normal blood concentration in clinic.

Description

A Method for Simultaneously Determining Plasma Concentration of Multiple Antiepileptic Drugs technical field The invention belongs to the field of medical testing, and relates to an analysis and determination method of drugs in vivo. In particular, it relates to a method capable of simultaneously measuring blood drug concentrations of multiple antiepileptic drugs. Background technique Primidone (PRI), phenobarbital (Phenobarbital, PB), phenytoin (Phenytoin, PHT), carbamazepine (Carbamazepine, CBZ) are traditional first-line antiepileptic drugs, and lamotrigine (Lamotrigen, LTG) and Oxcarbazepine (OXC) are the second-generation antiepileptic drugs that have been on the market in the past decade. OXC and CBZ can be metabolized into the active product monohydroxy oxcarbazepine (Monohydroxycarbazepine, MHD) and epoxy carbamazepine (Carbamazepine10, 11-epoxide, CBZE) respectively in the body. Because the pharmacokinetics of these drugs have large inter-individual differences ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/06G01N33/02G01N33/15
Inventor 焦正施孝金
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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