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Neisseria spp. polypeptide, nucleic acid sequence and uses thereof

a technology of nucleic acid sequence and neisseria spp., which is applied in the field of neisseria spp. polypeptide and nucleic acid sequence, can solve problems such as the treatment regimen of gonococcus, and achieve the effect of broad cross-strain protection and enhanced clearance of pathogens

Inactive Publication Date: 2004-09-30
JAMES W JACKSON +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention is about a new protein called NGSP, which is found in several species of Neisseria, including N. gonorrhoeae, N. ovis, N. lacunata, N. osloensis, and N. bovis. The protein has a molecular weight of about 40-55 kD and is highly conserved across different strains of Neisseria. The invention provides a method for identifying and using the NGSP protein, as well as pharmaceutical compositions containing it. The NGSP protein has been found to have similarities to other proteins in other bacteria, and the invention also provides methods for identifying compounds that interact with and inhibit or activate the NGSP protein. The invention also provides antibodies that are bactericidal and / or opsonic against Neisseria strains, which can protect against infection and enhance the clearance of the pathogen by the host's immune system."

Problems solved by technology

However, clinically significant resistance to fluoroquinolones has emerged in Neisseria gonorrhoeae and raised concerns regarding the future effectiveness and expense of anti-gonococcal treatment regimens.

Method used

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  • Neisseria spp. polypeptide, nucleic acid sequence and uses thereof
  • Neisseria spp. polypeptide, nucleic acid sequence and uses thereof

Examples

Experimental program
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Embodiment Construction

5.1. NGSP Polypeptide

[0039] The invention provides an isolated or a substantially pure native (wild type) or recombinantly produced polypeptide, referred to as NGSP, of Neisseria spp. including but is not limited to, Neisseria ovis, Neisseria lacunata, Neisseria osloensis, Neisseria bovis, and Neisseria gonorrhoeae , and various strains or cultivars thereof, but not of Neisseria meningitidis. The NGSP polypeptide comprises the whole or a subunit of a non-cytosolic protein embedded in, or located in the bacterial envelope, which may include the inner membrane, outer surface, and periplasmic space. The NGSP polypeptide has an apparent molecular weight, as determined from the deduced amino acid sequence, of about 40 kD to about 55 kD, preferably about 44 kD to about 53 kD.

[0040] NGSP polypeptide may also be identified as the polypeptide in hydrophobic (salt) or detergent extracts of Neisseria blebs or intact cells that has an apparent molecular weight about 40 kD to about 55 kD, prefer...

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Abstract

The invention discloses the Neisseria spp. NGSP polypeptide, polypeptides derived therefrom (NGSP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that specifically bind the NGSP polypeptide and / or NGSP-derived polypeptides. Also disclosed are prophylactic or therapeutic compositions, including antigenic, preferably immunogenic compositions, e.g., vaccines, comprising NGSP polypeptide and / or a NGSP-derived polypeptide or antibodies thereto. The invention additionally discloses methods of inducing an immune response to Neisseria and Neisseria NGSP polypeptide and an NGSP-derived polypeptide in animals.

Description

[0001] This application claims priority benefits of provisional U.S. application No. 60 / 098,685, filed Sep. 1, 1998, the entire disclosure of which is incorporated by reference herein.[0002] The present invention relates generally to a polypeptide of Neisseria spp., e.g., of N. gonorrhoeae, of approximately 40-55 kD referred to as "NGSP". The invention encompasses an isolated or purified NGSP polypeptide, fragments thereof and polypeptides derived therefrom (NGSP-derived polypeptides), and methods of making thereof. The invention also encompasses antibodies, including cytotoxic or bactericidal antibodies, that specifically bind the NGSP polypeptide, NGSP-derived polypeptides and / or fragments thereof. The invention further encompasses immunogenic, prophylactic or therapeutic compositions, including vaccines, that comprise NGSP polypeptide, NGSP-derived polypeptides and / or fragments thereof. The invention additionally provides methods of inducing an immune response to Neisseria gonorr...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/00A61K39/00C07K14/22
CPCA61K38/00C07K14/22A61K39/00
Inventor JAMES, W. JACKSONHARRIS, ANDREA M.
Owner JAMES W JACKSON
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