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Aequorin-containing compositions and methods of using same

a composition and aequorin technology, applied in the field of compositions useful for maintaining calcium homeostasis, can solve the problems of many of these calcium channel antagonists having unwanted side effects, malaise, fever, excessive bleeding, etc., and achieve the effect of preventing calcium imbalance and/or reducing the side effects

Inactive Publication Date: 2006-10-12
QUINCY BIOSCIENCE LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005] The present invention provides pharmaceutical and nutraceutical compositions useful in the alleviation and/or prevention of calcium imbalance. Such compositions include aequorin, a CaBP previously-known for its bioluminescence properties, in combination with acceptable carriers for administration to a subject by a variety of routes. Accordingly, the present invention is directed to pha

Problems solved by technology

However, many of these calcium channel antagonists have unwanted side effects including, but not limited to, malaise, fluid retention, heartburn, erratic heart rate, dizziness, upset stomach and, in rare cases, fainting, fever and excessive bleeding.

Method used

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Embodiment Construction

I. In General

[0008] Before the present methods are described, it is understood that this invention is not limited to the particular methodology and materials described, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims.

[0009] It must be noted that as used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural reference unless the context clearly dictates otherwise. As well, the terms “a” (or “an”), “one or more” and “at least one” can be used interchangeably herein. It is also to be noted that the terms “comprising”, “including”, and “having” can be used interchangeably.

[0010] Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this i...

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Abstract

Compositions containing aequorin and methods for their use in preventing and / or alleviating symptoms and disorders related to calcium imbalance are provided by the present invention.

Description

FIELD OF THE INVENTION [0001] This invention relates generally to compositions useful for the maintenance of calcium homeostasis. In particular, this invention is directed to aequorin-containing pharmaceutical and nutraceutical compositions useful in preventing and / or alleviating diseases or symptoms associated with calcium imbalance. BACKGROUND OF THE INVENTION [0002] Calcium is the fifth most abundant element in the human body and occurs mainly in the bone. More than 99% of the calcium in the body is stored in the skeleton, which constantly exchanges its supply with the remaining 1% dissolved in body fluids and soft tissue, such as the blood. The control of this exchange is largely dictated by the endocrine system which senses the concentration of ionized calcium in the plasma and directs calcium exchange to maintain this critical balance. Only a small fraction of the 1% of calcium in interstitial fluids and the soft tissues is ionized and soluble, the rest being bound to proteins...

Claims

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Application Information

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IPC IPC(8): A61K38/17
CPCA61K38/17A61P19/08A61P21/00A61P25/00A61P25/28A61P3/00A61P3/14A61P31/12A61P35/00A61P37/02A61P37/04A61P39/06A61P43/00A61P5/00A61P9/10
Inventor UNDERWOOD, MARK Y.
Owner QUINCY BIOSCIENCE LLC