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Extract of ogalpi, erectile dysfunction fanning healthy food and erectile dysfunction treating agent containing the same

a technology of ogalpi and erectile dysfunction, which is applied in the field of extract of ogalpi, can solve the problems of increasing the number of patients suffering from erectile dysfunction, increasing mental stress, and side effects

Inactive Publication Date: 2007-03-22
KOREA RES INST OF BIOSCI & BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006] It is an object of the present invention to provide an alcohol extract of ogalpi having an effect of improving erectile dysfunction.
[0009] In order to achieve the above object, the present invention provides an alcohol extract of ogalpi having an effect of improving erectile dysfunction.
[0013] The present invention provides an alcohol extract of ogalpi having an effect of improving erectile dysfunction.
[0016] When an extract extracted from roots or stems of any of Acanthopanax divaricatus var. albeofructus, Acanthopanax senticosus, Acanthopanax senticosus var. subinermis or Acanthopanax koreanum was treated to corpus cavernous smooth muscle of a rabbit, the relaxation of the smooth muscle thereof increased dose-dependently. The relaxation of the corpus cavernous smooth muscle was greater when an extract of Acanthopanax divaricatus var. albeofructus was treated, and a stem extract had better relaxing effect than a root extract (see FIG. 1a). And in the case of an extract extracted from the stems of ogalpi, 70% ethanol extract had better relaxing effect on corpus cavernous smooth muscle of a rabbit than distilled water extract (see FIG. 1b). When 70% alcohol extract prepared from the stems of Acanthopanax divaricatus var. albeofructus was orally administered to a white rat, erectibility of the penis of the white rat was increased dose and administration period-dependently (see FIG. 3). Therefore, an extract of ogalpi was proved to increase the penile erection by helping relaxation of corpus cavernous smooth muscle, and among extracts, 70% ethanol extract of the stems of Acanthopanax divaricatus var. albeofructus was confirmed to have the best relaxing effect.
[0022] An extract of the present invention strongly induced the relaxation of corpus cavernous smooth muscle of a rabbit. When the extract was orally administered to a white rat, the erectility increased dose- and administration time-dependently. Therefore, a composition of the present invention containing an extract of ogalpi as an effective ingredient can be effectively used for the improvement of erectile dysfunction.
[0026] The extract of the present invention showed a strong relaxing effect on corpus cavernous smooth muscle of a rabbit, and increased the erectility of a white rat, dose- and administration time-dependently, when it was orally administered. Thus, the extract of the present invention can be effectively used as a treating agent for erectile dysfunction.

Problems solved by technology

However, the number of patients suffering from erectile dysfunction is definitely being increased by the reasons of the expanded life span, the increase of adult diseases, change of diet, the increase of industrial and traffic accidents, the increase of mental stress and physical fatigue resulted from complicated modern life, etc.
However, such medicines have side effects and even their treating effects are in doubt.
However, there is no report on the effect of ogalpi on sexual function.

Method used

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  • Extract of ogalpi, erectile dysfunction fanning healthy food and erectile dysfunction treating agent containing the same
  • Extract of ogalpi, erectile dysfunction fanning healthy food and erectile dysfunction treating agent containing the same
  • Extract of ogalpi, erectile dysfunction fanning healthy food and erectile dysfunction treating agent containing the same

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Ogalpi Extracts

[0050] In order to prepare ogalpi extracts, Acanthopanax divaricatus var. albeofructus, Acanthopanax senticosus var. subinermis and Acanthopanax koreanum were obtained from Susin Ogapy Farm, Chonan, Korea, and Acanthopanax senticosus was collected in Chungok Mountain, Kangwon-Do, Korea. The roots and the stems were separated from each other and dried. After drying, they were cut into small pieces and put in 70% ethanol or distilled water, followed by extraction according to the standard of food and drug. Ogalpi extracts used in the present invention were classified according to the kinds of ogalpi and represented as follows; an extract of Acanthopanax divaricatus var. albeofructus was marked as H; an extract of Acanthopanax senticosus was marked as K; an extract of Acanthopanax senticosus var. subinermis was marked as M; and an extract of Acanthopanax koreanum was marked as S. More precisely, the groups were subdivided according to a part of the plants...

example 2

Relaxing Effect of Ogalpi Extract on Corpus Cavernous Smooth Muscle of a Rabbit (In Vitro Test)

2-1> Preparation of Slices of Corpus Cavernous Smooth Muscle of a Rabbit

[0051] 85 New Zealand white male rabbits (Samtaco BIO KOREA, Osan, Kyunggido, Korea) at the age of 4-6 months were selected as test animals because they have similar erection mechanism and structure of corpus cavernous smooth muscle to that of human. 30-50 mg / kg of sodium pentobarbital was injected into auricular vein of rabbits to put them under anesthesia. The penis of the animal was cut out and corpus cavernous smooth muscle of it was separated in a low-temperature tyrode solution (composition: (mEq / L) Na+ 153.6, K+ 5.3, Ca2+3.0, Mg2+1.2, Cl− 157.2, H2PO4− 0.6, SO4− 1.2, HCO3−7.1 and glucose 5.0) supplied with a mixed gas of 95% O2 and 5% CO2. The separated corpus cavernous smooth muscle was sliced as thin as 2×2×6 mm, which was fixed in 10 ml organ bath containing tyrode solution. The movement of the corpus cave...

example 3

Effect of Ogalpi Extract on cGMP and CAMP Concentrations in Corpus Cavernous Smooth Muscle of a Rabbit (In Vitro Test)

[0062] After contracting corpus cavernous smooth muscle of a rabbit by PHE, ogalpi extract was administered thereto to induce relaxation. Under the maximum relaxation, tissues were immediately frozen and kept in −70° C. Then, enzyme immunoassay (EIA) was performed using cGMP and cAMP analyzing kit (BIOTRA cellular communication assays kit) (Amersham pharmcia biotech, Buckinghamshire UK) to measure the contents of cGMP and cAMP.

[0063] As a result, the concentrations of cGMP and cAMP were increased by the treatment of ogalpi extract, HS, dose-dependently in the slice of corpus cavernous smooth muscle contracted by PHE (FIG. 2).

[0064] The excel program was used to calculate mean values and standard deviations from all the results obtained through example 1 to example 4. Mann-Whitney U test or student's t test was performed to judge the significance among all the resu...

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Abstract

The present invention relates to an alcohol extract of ogalpi, erectile dysfunction improving health food and a treating agent containing the same, more precisely, an alcohol extract of ogalpi having an effect of improving erectile dysfunction, erectile dysfunction improving health food and an erectile dysfunction treating agent containing the same. The alcohol extract of ogalpi of the present invention has a promoting effect of penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.

Description

TECHNICAL FIELD [0001] The present invention relates to an extract of ogalpi, more precisely, an alcohol extract of ogalpi having an effect of improving erectile dysfunction and erectile dysfunction improving health food and an erectile dysfunction treating agent containing the same. BACKGROUND ART [0002] The penile erection, coming through a complicated physiological pathway involved in not only blood vessel system but also endocrine and nervous system, is induced by a chain of phases such as relaxation of corpus cavernous smooth muscle by a variety of stimuli, increase of blood flow by the inflation of a small hole and the expansion of an arteriole, increase of the inside pressure of the penis, decrease of the venous outflow by compressing of the subtunical venular plexuses between the tunica albuginea and the peripheral sinusoids, and then increase of the inner pressure of the penis more (Lue T F, Tanagho E A., J Urol, 1987, 137, 829-36). With the physiological explanation of the...

Claims

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Application Information

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IPC IPC(8): A61K36/258A21D2/14A21D2/36A21D13/08A23G1/48A23G3/48A23G4/06A23G9/42A23L1/30A23L2/52A23L33/00A61K36/00A61K36/254A61P15/10
CPCA21D2/14A21D2/36A21D13/08A23G1/48A61K36/254A23G4/068A23G9/42A23L1/3002A23L2/52A23G3/48A23L33/105A21D13/80A61P15/10
Inventor LEE, JUNG JOONLEE, JEONG-HYUNGHONG, YOUNG SOOKIM, YOUNG HOCHOI, YOUNG DEUK
Owner KOREA RES INST OF BIOSCI & BIOTECH
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