Methods and compositions for preventing and treating aging or photodamaged skin

a technology for aging or photodamage skin, applied in the field of dermatological conditions, can solve the problems of increasing the structure and function of skin changes, and achieve the effects of reducing the signs of aging and photodamage in the treated skin, stimulating collagen synthesis, and enhancing the proliferation and viability of dermal fibroblasts

a technology for aging or photodamage skin, applied in the field of dermatological conditions, can solve the problems of increasing the structure and function of skin changes, and achieve the effects of reducing the signs of aging and photodamage in the treated skin, stimulating collagen synthesis, and enhancing the proliferation and viability of dermal fibroblasts

US20080255032A1Inactive Publication Date: 2008-10-16PROCYTE
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  • Methods and compositions for preventing and treating aging or photodamaged skin
  • Methods and compositions for preventing and treating aging or photodamaged skin
  • Methods and compositions for preventing and treating aging or photodamaged skin

Examples

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Effect test

example 1

[0079]The composition of a representative moisturizing lotion used for a method of the present invention is shown below.

REPRESENTATIVE MOISTURIZING LOTIONIngredients% w / wWater73.80%Glycerin1.00%Hydroxyethylcellulose0.50%diisopropyl adipate4.00%isocetyl palmitate6.00%octyl stearate10.00%glyceryl monooleate1.00%cetyl alcohol1.00%stearyl alcohol0.80%behenyl alcohol0.50%palmitic acid0.25%stearic acid0.25%L-alanyl-L-histidyl-L-lysine manganese0.30%complexpropylene glycol0.55%Phenoxyethanol0.30%iodopropynyl butylcarbonate0.02%total100.00%

example 2

[0080]The composition of a representative moisturizing cream used for a method of the present invention is shown below.

REPRESENTATIVE MOISTURIZING CREAMIngredients% w / wpurified water77.35%ethylhexyl palmitate8.00%Octyldodecanol2.50%butyloctyl calicylate2.00%Squalane1.50%jojoba oil0.50%tocopheryl acetate0.20%Bisabolol0.20%Polyacrylamide1.50%laureth-70.50%Glycerin3.00%Panthenol0.60%Allantion0.10%Cyclomethicone0.50%Hydroxyethylcellulose0.10%polysorbate 200.20%glycyl-L-histidyl-L-lysine manganese0.25%complexpropylene glycol0.56%diazolidinyl urea0.30%Methylparaben0.11%Propylparaben0.03%total100.00%

example 3

Stimulation of Collagen Formation in Fibroblasts by a Peptide Manganese Complex

[0081]The effect of peptide manganese complexes on collagen formation was determined by determining the amount of collagen type I produced by human fibroblasts in cell culture. Normal human dermal fibroblasts were seeded into a 96-well cell culture plate and grown to confluence in high glucose media supplemented with 10% fetal calf serum for 3 days. The fibroblasts were then placed in low glucose media with 2% serum and various amounts of a representative peptide manganese complex. After 3 days, the culture media was collected and analyzed for collagen type I content by a sandwich ELISA assay using purified antibody to collagen type I.

[0082]The results, shown in Table 4, show that the addition of GHK-Mn complex (glycyl-L-histidyl-L-lysine manganese) stimulated the formation of collagen type I.

TABLE 4Stimulation of Collagen Type I Synthesis in Dermal FibroblastsBy Glycyl-L-Histidyl-L-Lysine Manganese Compl...

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Abstract

Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods wherein the composition further comprises retinol, at least one retinol derivative, or a mixture thereof and methods wherein the composition further comprises active agents selected from active drug substances, emollients, sunscreen agents, skin lightening agents, skin protectants, skin conditioning agents, humectants, and mixtures thereof.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 11 / 376,728, filed Mar. 15, 2006 (now allowed), which claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application No. 60 / 662,577 filed Mar. 16, 2005. These applications are incorporated herein by reference in their entireties.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention generally relates to the treatment of dermatological conditions and, more specifically, to the treatment of conditions related to aging or photodamaged skin, by topical application of a composition comprising a peptide manganese complex.[0004]2. Description of the Related Art[0005]Aging and photodamage result in a number of changes in the structure and function of skin. Primary among these changes is a thinning of the skin due to lower levels of collagen, elastin and other components of the skin's connective tissue. Lower levels of synthesi...

Claims

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Application Information

Patent Timeline
16 Oct 2008
Publication
US20080255032A1
IPC
A61K38/06; A61P17/02
CPC
A61K8/19; A61K8/64; A61K38/05; A61K2800/58; A61Q19/08; A61P17/02
Inventors
PATT, LEONARD M.