Use of flavonoids as immunomodulating or immuno-protective agents in cosmetic and dermatological preparations

Abstract

A method of treating or prophylactically treating immunosuppression or allergic and inflammatory symptoms of skin caused by UVB radiation which comprises applying to the skin a cosmetic or dermatological composition which comprises one or more flavonoids.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation of U.S. application Ser. No. 08 / 849,525, the entire disclosure of which is expressly incorporated by reference herein, which is a National Stage of International Application PCT / EP95 / 04908, filed Dec. 12, 1995, which claims priority of German Patent Application No. 44 44 238.6, filed Dec. 13, 1994.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to active compounds and formulations comprising such active compounds for cosmetic or dermatological treatment and / or prophylaxis of inflammatory, allergic or autoimmune-reactive symptoms, and protecting cells which participate in the immune response of the skin.[0004]2. Discussion of Background Information[0005]As a barrier organ in the human organism, the skin, especially the epidermis, is particularly subjected to external effects. According to current scientific understanding, the skin represents an immunolo...

AI Technical Summary

Benefits of technology

[0041]It may also be advantageous to omit the above-mentioned glycosidic radicals Gly1-3 and to use the unsubstituted flavonoids (Gly1-3═H), such as, for example, quercitin. It may also be of advantage to use flavonoids in which the glucoside radical is bonded to C7, C4′, C3′ or C5′ via phenolic OH functions.

Problems solved by technology

Ultraviolet light from the wavelength range between about 320 and 400 nm (UVA range) can also cause secondary damage to the skin.

It has thus been proved that UVA radiation also leads to damage to the elastic and collagenic fibres of connective tissue, which causes the skin to age prematurely (so-called photoageing), and that it is to be regarded as a cause of numerous phototoxic toxic and phototoxic and photoallergic reactions.

Undefined free-radical photo products which are formed in the skin itself can also show uncontrolled secondary reactions because of their high reactivity.

Furthermore, the activity of vitamin E from topical vehicles was weak.

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