Mesothelin, A Differentiation Antigen Present On Mesothelium, Mesotheliomas, and Ovarian Cancers and Methods and Kits for Targeting the Antigen

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US20090280556A1Inactive Publication Date: 2009-11-12THE GOVT OF THE U S A AD REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE GOVT OF THE U S A AD REPRESENTED BY THE SEC OF THE DEPT OF HEALTH & HUMAN SERVICES
Publication Date
2009-11-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to the discovery of a differentiation antigen termed mesothelin which is associated with mesotheliomas and ovarian cancers. Mesothelin is about 69 kD in its full-length form. The invention includes uses for the amino acid and nucleic acid sequences for mesothelin, recombinant cells expressing it, methods for targeting and / or inhibiting the growth of cells bearing mesothelin, methods for detecting the antigen and its expression level as an indication of the presence of tumor cells, and kits for such detection.
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Description

CROSS-REFERENCES TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 09 / 684,599, filed Oct. 5, 2000, which is a divisional of U.S. patent application Ser. No. 09 / 215,035, filed Dec. 17, 1999, now U.S. Pat. No. 6,153,430, which was a divisional of U.S. patent application Ser. No. 08 / 776,271, filed Jan. 12, 1998, now U.S. Pat. No. 6,083,502, which was a national stage application under 35 U.S.C. § 371 of PCT / US97 / 00224, filed Jan. 3, 1997, which claims priority from U.S. Provisional Application No. 60 / 010,166, filed Jan. 5, 1996. The contents of each of these applications is hereby incorporated by reference.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT

[0002] Not applicable.FIELD OF THE INVENTION

[0003] This invention relates to the identification of a specific antigen found on tumor cells, particularly mesotheliomas and ovarian tumor cells and, inter alia, methods and compositions for targeting...

Claims

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