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Oral insulin composition and methods of making and using thereof

a composition and oral technology, applied in the field of oral insulin compositions, can solve the problems of complex multi-step method, inconvenient and painful method of administering composition, and the inability to manufacture cross-linked dextran beads, etc., and achieve the effect of lowering blood glucose and lowering blood glucose of the mammal

Inactive Publication Date: 2010-07-01
THE TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, beads based on cross-linked dextran generally cannot be used for implant manufacturing owing to their potential toxicity due to the application of cross-linking agents (Blain J. F., Maghni K., Pelletier S. and Sirois P. Inflamm. Res. 48 (1999): 386-392).
Schroder's multi-step method is complex and uses organic solvents that are potentially toxic to cells and need to be removed.
Furthermore, Schroder's composition is designed for injection, which is an inconvenient and painful method of administering the composition.

Method used

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  • Oral insulin composition and methods of making and using thereof
  • Oral insulin composition and methods of making and using thereof
  • Oral insulin composition and methods of making and using thereof

Examples

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Embodiment Construction

[0018]The present inventor discovered that a composition of porous (i.e., microporous) microparticles, such as crystallized dextran microparticles, may be used as a vehicle for oral delivery of insulin. The composition may be a one phase composition or a multi-phase composition which forms a structured implant in a mammal.

[0019]The first section below describes the preferred crystallized dextran microparticles, the second section describes formation of the structured implant from a multi-phase composition, and the following sections describe specific examples of oral administration of the composition into mammals and methods of making the oral insulin composition.

A. Crystallized Dextran Microparticles

[0020]The present inventor has experimentally found that crystallized dextran microparticles with an average diameter ranging from 0.5 to 3.5 microns were spontaneously formed in concentrated aqueous solutions of dextrans (40-65% W / W) with molecular weights ranging from 1.0 to 200.0 kDa...

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Abstract

A method of lowering blood glucose in a mammal includes orally administering a therapeutically effective amount of crystallized dextran microparticles and insulin to the mammal to lower blood glucose of the mammal. The composition may be a one phase or a structured multi-phase composition for controlled release of insulin.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 10 / 792,376, filed Mar. 4, 2004, which claims priority to U.S. Provisional Patent Application Ser. No. 60 / 451,245, filed Mar. 4, 2003; U.S. Provisional Patent Application Ser. No. 60 / 467,601, filed May 5, 2003; U.S. Provisional Patent Application Ser. No. 60 / 469,017, filed May 9, 2003; and U.S. Provisional Patent Application Ser. No. 60 / 495,097, filed Aug. 15, 2003, the disclosures of each of the foregoing applications being incorporated by reference herein in their entirety.FIELD OF THE INVENTION[0002]The present invention relates generally to insulin compositions and specifically to an oral insulin composition containing insulin and crystallized dextran microparticles.BACKGROUND OF THE INVENTION[0003]Dextrans are high molecular weight polysaccharides synthesized by some micro organisms or by biochemical methods. Dextran with average molecular weight of about 75 kDa ha...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/00A61P3/10A61K9/107A61K9/16A61K9/50A61K38/28A61K47/36
CPCA61K9/0095A61K9/107A61K9/1652A61K9/1676A61K38/28A61K47/36A61P3/10A61P43/00A61P5/48A61P5/50
Inventor SABETSKY, VLADIMIR
Owner THE TECH DEV CO LTD